gene

NOD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

320Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NOD2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 158 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOD2
Function	NOD2 encodes nucleotide-binding oligomerization domain-containing protein 2, an intracellular pattern recognition receptor that senses bacterial muramyl dipeptide (MDP).
Primary Expression	the brain and may contribute to neurodegeneration:
Pathways	NF-κB
Ensembl ID	ENSG00000105904
GeneCards	NOD2
Human Protein Atlas	NOD2
Innate immune sensing	Recognizes bacterial components and initiates inflammatory responses
[NF-κB](/entities/nf-kb) activation	Triggers pro-inflammatory signaling cascades
Mucosal defense	Critical for intestinal barrier function
Anti-microbial peptides	Induces alpha-defensin production in Paneth cells
Associated Diseases	Als, Atherosclerosis, Cancer, Colorectal Cancer, Crohn's disease, IBD
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	320 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NOD2 Gene

gene · 529 words

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Pathway Diagram

graph TD
    NOD2["NOD2"]
    NOD2 -->|"causes"| Crohn_s_disease["Crohn's disease"]
    NOD2 -->|"regulates"| Als["Als"]
    NOD2 -->|"regulates"| Inflammation["Inflammation"]
    NOD2 -->|"expressed in"| Ms["Ms"]
    NOD2 -->|"activates"| Alzheimer["Alzheimer"]
    NOD2 -->|"activates"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    NOD2 -->|"activates"| Stroke["Stroke"]
    NOD2 -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    P62["P62"] -->|"regulates"| NOD2
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| NOD2
    MICROGLIA["MICROGLIA"] -->|"expressed in"| NOD2
    CYTOKINES["CYTOKINES"] -->|"expressed in"| NOD2
    CCL5["CCL5"] -->|"expressed in"| NOD2
    TNF["TNF"] -->|"expressed in"| NOD2
    NF__B["NF-KappaB"] -->|"expressed in"| NOD2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| NOD2
    NF_KB["NF-KB"] -->|"activates"| NOD2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| NOD2

Outgoing (204)

Target	Relation	Type	Str
Crohn's disease	causes	disease	0.90
Inflammatory Response	involved_in	process	0.85
RIPK2	interacts_with	protein	0.85
RIPK2	recruits	gene	0.80
IBD	associated_with	disease	0.80
Innate Immunity	involved_in	pathway	0.80
innate immunity	involved_in	pathway	0.80
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
Immune Response	activates	pathway	0.70
Mapk	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
necroptosis	participates_in	pathway	0.70
Cardiovascular	expressed_in	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Inflammatory Bowel Disease	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Crohn Disease	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Als	associated_with	disease	0.65
Anxiety	regulates	disease	0.65
Infection	regulates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Lymphoma	activates	disease	0.65
Depression	regulates	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Inflammasome	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
STROKE	activates	gene	0.60
MAPK	activates	gene	0.60
NF-KB	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60

Incoming (116)

Source	Relation	Type	Str
PYCARD	associated_with	gene	0.70
TNF	associated_with	gene	0.70
CASP1	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60
XIAP	activates	gene	0.60
AKT1	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
GNB1	interacts_with	gene	0.60
AMPD2	expressed_in	gene	0.60
ATG5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
CLCN7	expressed_in	gene	0.60
RIPK2	interacts_with	gene	0.60
IFIH1	interacts_with	gene	0.60
GNAI1	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
GNG2	interacts_with	gene	0.60
WDR81	expressed_in	gene	0.60
GNPTG	expressed_in	gene	0.60
GNAI2	interacts_with	gene	0.60
PTEN	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
IL10	activates	gene	0.60
IL1B	activates	gene	0.60
ASC	activates	gene	0.60
BRG1	activates	gene	0.60
LC3	activates	gene	0.60
MTOR	activates	gene	0.60
CTSB	associated_with	gene	0.60
DYRK1A	associated_with	gene	0.60
FYN	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
ZFP36	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NF-KB	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
GENE MUTATIONS	associated_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
NLR	associated_with	gene	0.60
CCDC50	activates	gene	0.60
HMOX1	associated_with	gene	0.60
P62	regulates	gene	0.60
RIPK2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity