concept

GENE MUTATIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GENE MUTATIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

471Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GENE MUTATIONS is a concept in neurodegeneration research. Key relationships include: therapeutic target, activates, associated with. Associated with ALS, Aging, Als. Connected to 339 entities in the SciDEX knowledge graph.

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Pathway Diagram

graph TD
    GENE_MUTATIONS["GENE MUTATIONS"]
    GENE_MUTATIONS -->|"causes"| dysregulated_pathways["dysregulated pathways"]
    GENE_MUTATIONS -->|"causes"| ALS["ALS"]
    GENE_MUTATIONS -->|"target for"| Cancer["Cancer"]
    GENE_MUTATIONS -->|"activates"| Parkinson["Parkinson"]
    GENE_MUTATIONS -->|"activates"| Ms["Ms"]
    GENE_MUTATIONS -->|"activates"| Als["Als"]
    GENE_MUTATIONS -->|"activates"| Autoimmune["Autoimmune"]
    GENE_MUTATIONS -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TP53["TP53"] -->|"target for"| GENE_MUTATIONS
    CANCER["CANCER"] -->|"target for"| GENE_MUTATIONS
    RB1["RB1"] -->|"target for"| GENE_MUTATIONS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| GENE_MUTATIONS
    MITOPHAGY["MITOPHAGY"] -->|"activates"| GENE_MUTATIONS
    PARKIN["PARKIN"] -->|"activates"| GENE_MUTATIONS
    PTEN["PTEN"] -->|"activates"| GENE_MUTATIONS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| GENE_MUTATIONS
    CGAS["CGAS"] -->|"activates"| GENE_MUTATIONS
    PI3K["PI3K"] -->|"activates"| GENE_MUTATIONS

Outgoing (276)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GENE MUTATIONS	data_in	dataset_row	0.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Als	treats	disease	0.85
Parkinson's Disease	risk_factor_for	disease	0.85
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.85
Parkinson	therapeutic_target	disease	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Angiogenesis	therapeutic_target	pathway	0.80
Als	activates	disease	0.75
Cancer	associated_with	disease	0.75
Parkinson	activates	disease	0.75
Als	associated_with	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Epigenetic	therapeutic_target	pathway	0.70
Histone Modification	therapeutic_target	pathway	0.70
Mitochondrial Function	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
Autophagy	activates	pathway	0.70
CANCER	activates	gene	0.70
ALS	causes	disease	0.70
dysregulated pathways	causes	pathway	0.70
MITOPHAGY	activates	gene	0.70
Immunotherapy	therapeutic_target	pathway	0.70
Gastric Cancer	therapeutic_target	disease	0.65
Cancer	causes	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Glaucoma	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	causes	disease	0.65
Tumor	causes	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Als	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Cancer	activates	disease	0.65
Ataxia	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neuropathy	activates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Pain	activates	disease	0.65
Retinitis Pigmentosa	activates	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65

Incoming (195)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GENE MUTATIONS	data_in	dataset_row	0.00
CANCER	therapeutic_target	gene	1.00
Alzheimer'S Disease	associated_with	disease	0.95
DNA	associated_with	gene	0.80
DNA	therapeutic_target	gene	0.80
PARKINSON'S DISEASE	therapeutic_target	gene	0.80
PARKINSON	therapeutic_target	gene	0.80
ALS	associated_with	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
GENES	therapeutic_target	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.70
SOD1	therapeutic_target	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
GENES	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
ALS	treats	gene	0.70
TP53	associated_with	gene	0.70
P53	associated_with	gene	0.70
CANCER	associated_with	gene	0.70
EGFR	activates	gene	0.70
MLH1	therapeutic_target	gene	0.60
BRCA1	therapeutic_target	gene	0.60
PALB2	therapeutic_target	gene	0.60
TCF3	activates	gene	0.60
LRP1	activates	gene	0.60
RRM1	activates	gene	0.60
YBX1	activates	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
HUNTINGTON'S DISEASE	therapeutic_target	gene	0.60
NRF2	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
DNA	implicated_in	gene	0.60
MDM2	implicated_in	gene	0.60
GENES	implicated_in	gene	0.60
RAS	activates	gene	0.60
ALS	causes	gene	0.60
MOTOR NEURONS	causes	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
NEURON	causes	gene	0.60
AND	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
BRAF	activates	gene	0.60
KRAS	activates	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
FERROPTOSIS	interacts_with	gene	0.60
TP53	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity