gene 1,887 words KG: CNTNAP3
Contents

CNTNAP3 Gene - Contactin Associated Protein 3

🧬 Gene Info
Gene SymbolCNTNAP3
FunctionCNTNAP3 belongs to the CNTNAP (Contactin-Associated Protein) subfamily of neurexin-related molecules
Primary Expressionthe brain, where it localizes to both presynaptic and postsynaptic compartments, suggesting roles in bidirectional synaptic communication[@rozemann201
Amino Acids1395 aa
PathwaysAutophagy
Ensembl IDENSG00000178199
GeneCardsCNTNAP3
Human Protein AtlasCNTNAP3
PDZ-binding motifC-terminal sequence interacts with PSD-95 and other scaffolding proteins
N-glycosylation sitesMultiple sites for post-translational modification
NeurexinsMay form heterodimeric complexes with neurexin family members
Calcium channelsInteraction with voltage-gated calcium channels
Synaptic vesicle proteinsPotential roles in neurotransmitter release
NeuroliginsBinding to postsynaptic neuroligins for trans-synaptic adhesion
PSD-95 familyThrough PDZ-binding motif
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAUTOPHAGY
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (9)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (4)

Neurodegeneration
disease · KG edge: implicated_in
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: expressed_in
NOD2 Gene
gene · KG edge: associated_with

Knowledge Graph (5 edges)

NOD2 associated_with CNTNAP3
CNTNAP3 expressed_in ATG16L1
GENE MUTATIONS associated_with CNTNAP3
AUTOPHAGY activates CNTNAP3
CNTNAP3 activates Autophagy

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