Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COX5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | COX5A |
| Full Name | Cytochrome C Oxidase Subunit 5A |
| Chromosome | 15q15.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | tissues with high oxidative metabolism, including: |
| Molecular Weight | 16 kDa |
| Amino Acids | 150 aa |
| Pathways | NAD+ metabolism |
| UniProt ID | [P20674](https://www.uniprot.org/uniprot/P20674) |
| Ensembl ID | ENSG00000178741 |
| GeneCards | COX5A |
| Human Protein Atlas | COX5A |
| Neurons | high energy demand for synaptic function |
| Cardiac muscle | continuous contraction |
| Skeletal muscle | exercise-induced mitochondrial biogenesis |
| Associated Diseases | neurodegeneration |
| Interactions | NRF1, SIRT3, TFAM |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
COX5A["<b>COX5A</b>"]
Carcinoma{"Carcinoma"}
COX5A -->|"inhibits"| Carcinoma
Ms{"Ms"}
COX5A -->|"inhibits"| Ms
Tumor{"Tumor"}
COX5A -->|"contributes to"| Tumor
PRDX6["PRDX6"]
COX5A -->|"contributes to"| PRDX6
PRDX3["PRDX3"]
COX5A -->|"contributes to"| PRDX3
SOD2["SOD2"]
COX5A -->|"contributes to"| SOD2
OXIDATIVE_STRESS["OXIDATIVE STRESS"]
COX5A -->|"contributes to"| OXIDATIVE_STRESS
Oxidative_Stress(["Oxidative Stress"])
COX5A -->|"contributes to"| Oxidative_Stress
neurodegeneration["neurodegeneration"]
COX5A -->|"implicated in"| neurodegeneration
style COX5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Tumor | contributes_to | disease | 0.65 |
| PRDX6 | contributes_to | gene | 0.60 |
| PRDX3 | contributes_to | gene | 0.60 |
| SOD2 | contributes_to | gene | 0.60 |
| OXIDATIVE STRESS | contributes_to | gene | 0.60 |
| Oxidative Stress | contributes_to | pathway | 0.60 |
| NRF1 | inhibits | gene | 0.55 |
| SIRT3 | inhibits | gene | 0.55 |
| TFAM | inhibits | gene | 0.55 |
| NAD+ metabolism | participates_in | pathway | 0.55 |
| excitatory neurons | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||