entity

excitatory neurons

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about excitatory neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

1Hypotheses

1Analyses

5Outgoing

17Incoming

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Outgoing (9)

Target	Relation	Type	Str
oxidative stress response	active_in	pathway	0.65
NAD+ metabolism	active_in	pathway	0.55
calcium signaling	active_in	pathway	0.55
mitochondrial function	active_in	pathway	0.55
unfolded protein response	active_in	pathway	0.55

Incoming (21)

Source	Relation	Type	Str
C1QA	expressed_in	gene	0.75
BDNF	expressed_in	protein	0.70
SLC17A7	expressed_in	gene	0.65
APOE	expressed_in	gene	0.55
GFAP	expressed_in	gene	0.55
TREM2	expressed_in	gene	0.55
SIRT3	expressed_in	gene	0.55
NRF1	expressed_in	gene	0.55
TFAM	expressed_in	gene	0.55
COX5A	expressed_in	gene	0.55
RORB	expressed_in	gene	0.55
PINK1	expressed_in	gene	0.55
VGLUT1	expressed_in	gene	0.55
TH	expressed_in	gene	0.55
IDH2	expressed_in	gene	0.55
ATP	expressed_in	gene	0.55
ROS	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer V excitatory neurons show selectively enhanced vulnera	0.510	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026	0

excitatory neurons

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

GRIA3 Gene

ncam2

gabaergic-dysfunction

dendritic-spines

Spinal Cord Dorsal Horn Neurons

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

NPAS3 Gene

RNA Metabolism Dysregulation in Alzheimer's Disease

Nanomedicine Approaches to Alzheimer's Disease

Retromer Dysfunction in Corticobasal Syndrome

Calcium Signaling Dysregulation in Alzheimer's Disease

Transcranial Direct Current Stimulation-Affected Neurons

MAPK9 Gene

SETD1B

ROCK1 Gene

Allen Institute for Neural Dynamics

Hippocampal CA3 Pyramidal Neurons in Epilepsy