concept

EXCITATORY NEURONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXCITATORY NEURONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

2Hypotheses

1Analyses

10Outgoing

25Incoming

0Experiments

2Debates

No summary available yet.

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💡 Concept Info

Name	EXCITATORY NEURONS

Pathway Diagram

graph TD
    EXCITATORY_NEURONS[EXCITATORY NEURONS]
    EXCITATORY_NEURONS -->|interacts| inhibitory_neurons[inhibitory neurons]
    EXCITATORY_NEURONS -->|contributes to| Motor_Recovery[Motor Recovery]
    EXCITATORY_NEURONS -->|active_in| oxidative_stress_response[oxidative stress response]
    EXCITATORY_NEURONS -->|active_in| NAD__metabolism[NAD+ metabolism]
    EXCITATORY_NEURONS -->|active_in| calcium_signaling[calcium signaling]
    EXCITATORY_NEURONS -->|active_in| mitochondrial_function[mitochondrial function]
    EXCITATORY_NEURONS -->|active_in| unfolded_protein_response[unfolded protein response]
    SNCA[SNCA] -->|expressed in| EXCITATORY_NEURONS
    COHESIN_COMPLEX[COHESIN COMPLEX] -->|upregulates| EXCITATORY_NEURONS
    Cohesin_Complex[Cohesin Complex] -->|expressed in| EXCITATORY_NEURONS
    C1QA[C1QA] -->|expressed in| EXCITATORY_NEURONS
    BDNF[BDNF] -->|expressed in| EXCITATORY_NEURONS
    SLC17A7[SLC17A7] -->|expressed in| EXCITATORY_NEURONS
    APOE[APOE] -->|expressed in| EXCITATORY_NEURONS
    GFAP[GFAP] -->|expressed in| EXCITATORY_NEURONS
    TREM2[TREM2] -->|expressed in| EXCITATORY_NEURONS
    SIRT3[SIRT3] -->|expressed in| EXCITATORY_NEURONS

Outgoing (10)

Target	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.90
AD Pathology	associated_with	process	0.82
inhibitory neurons	interacts_with	cell_type	0.80
Motor Recovery	contributes_to	phenotype	0.70
bioenergetic stress	associated_with	phenotype	0.70
oxidative stress response	active_in	pathway	0.65
NAD+ metabolism	active_in	pathway	0.55
mitochondrial function	active_in	pathway	0.55
unfolded protein response	active_in	pathway	0.55
calcium signaling	active_in	pathway	0.55

Incoming (25)

Source	Relation	Type	Str
SNCA	expressed_in	gene	0.90
39402379	lost during	paper	0.90
28798132	showed stronger cross-species conservation than in	paper	0.90
34616066	resemble	paper	0.90
COHESIN COMPLEX	upregulates	protein	0.85
Cohesin Complex	expressed_in	protein	0.85
DNA Damage Response	associated_with	pathway	0.80
C1QA	expressed_in	gene	0.75
BDNF	expressed_in	protein	0.70
SLC17A7	expressed_in	gene	0.65
21283555	show	paper	0.60
IDH2	expressed_in	gene	0.55
TH	expressed_in	gene	0.55
ATP	expressed_in	gene	0.55
ROS	expressed_in	gene	0.55
NRF1	expressed_in	gene	0.55
GFAP	expressed_in	gene	0.55
COX5A	expressed_in	gene	0.55
RORB	expressed_in	gene	0.55
PINK1	expressed_in	gene	0.55
VGLUT1	expressed_in	gene	0.55
APOE	expressed_in	gene	0.55
TFAM	expressed_in	gene	0.55
TREM2	expressed_in	gene	0.55
SIRT3	expressed_in	gene	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer V excitatory neurons show selectively enhanced vulnera	0.632	alzheimers	SEA-AD Single-Cell Analysis: Cell-Type V
BIN1 Neuronal Isoform Restoration in Vulnerable Excitatory N	0.000	-	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (1)

Scientific analyses that reference this entity

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

neurodegeneration | 2026-04-04 | 5 hypotheses Top: 0.661

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026	0

Debates (2)

Multi-agent debates referencing this entity

Debate: Microglial TREM2 downregulation impairs damage-associated response in la

closed · Rounds: 4 · Score: 0.21 · 2026-04-27

SEA-AD Single-Cell Analysis: Cell-Type Vulnerability in Alzheimer's Disease

closed · Rounds: 4 · Score: 0.88 · 2026-04-04

Related Research

Hypotheses and analyses mentioning EXCITATORY NEURONS in their description or question text

No additional research found