Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRDX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PRDX6 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, contributes to. Associated with Aging, Als, Cancer. Connected to 100 entities in the SciDEX knowledge graph.
| Gene Symbol | PRDX6 |
| Full Name | Peroxiredoxin 6 |
| Chromosome | 1q25.1 |
| Function | is a unique member of the peroxiredoxin family with distinctive dual enzyme activities that set it apart from other peroxiredoxins. |
| Primary Expression | Brain, Liver, Lung, Heart, Kidney |
| Molecular Weight | 25 kDa |
| Amino Acids | 224 aa |
| Exons | 9 |
| Pathways | Mitophagy |
| UniProt ID | P30041 |
| NCBI Gene ID | 9588 |
| Ensembl ID | ENSG00000119004 |
| OMIM | 603351 |
| GeneCards | PRDX6 |
| Human Protein Atlas | PRDX6 |
| Associated Diseases | Aging, Als, Cancer, Cardiovascular, Ms, Tumor |
| Interactions | MAPK14, BECN1, TNF, ECSIT, MAP3K7, TLR4 |
| KG Connections | 214 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PRDX6["PRDX6"]
PRDX6 -->|"activates"| Cancer["Cancer"]
PRDX6 -->|"inhibits"| Hepatitis["Hepatitis"]
PRDX6 -->|"inhibits"| Carcinoma["Carcinoma"]
PRDX6 -->|"inhibits"| Als["Als"]
PRDX6 -->|"inhibits"| Cirrhosis["Cirrhosis"]
PRDX6 -->|"inhibits"| Ms["Ms"]
PRDX6 -->|"contributes to"| Tumor["Tumor"]
PRDX6 -->|"activates"| MAPK14["MAPK14"]
PRDX6 -->|"activates"| BECN1["BECN1"]
PRDX6 -->|"activates"| TNF["TNF"]
CKB["CKB"] -->|"interacts"| PRDX6
P38["P38"] -->|"activates"| PRDX6
MAP1LC3["MAP1LC3"] -->|"activates"| PRDX6
IL1B["IL1B"] -->|"activates"| PRDX6
PRDX1["PRDX1"] -->|"activates"| PRDX6
TRAF6["TRAF6"] -->|"activates"| PRDX6
CHUK["CHUK"] -->|"activates"| PRDX6
PARKIN["PARKIN"] -->|"inhibits"| PRDX6
TLR4["TLR4"] -->|"activates"| PRDX6
UBIQUITIN["UBIQUITIN"] -->|"activates"| PRDX6| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | associated_with | process | 0.95 |
| PARKIN | interacts_with | protein | 0.90 |
| mitophagy | inhibits | process | 0.90 |
| M1 Microglia | regulates | phenotype | 0.85 |
| Astrocytes | modulates | cell_type | 0.80 |
| Cancer | activates | disease | 0.65 |
| Hepatitis | inhibits | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Cirrhosis | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Tumor | contributes_to | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Hepatocellular Carcinoma | inhibits | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Neuroinflammation | interacts_with | disease | 0.65 |
| Inflammation | interacts_with | disease | 0.65 |
| MAPK14 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| ECSIT | activates | gene | 0.60 |
| MAP3K7 | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| RELA | activates | gene | 0.60 |
| TAK1 | activates | gene | 0.60 |
| IKBKB | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MYC | inhibits | gene | 0.60 |
| ACTB | associated_with | gene | 0.60 |
| PRDX1 | activates | gene | 0.60 |
| PARKIN | inhibits | gene | 0.60 |
| YWHAZ | contributes_to | gene | 0.60 |
| MAPK14 | contributes_to | gene | 0.60 |
| LMNA | contributes_to | gene | 0.60 |
| RAGE | associated_with | gene | 0.60 |
| PRDX3 | contributes_to | gene | 0.60 |
| SOD2 | contributes_to | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| TRAF6 | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MIZ1 | binds_to | protein | 0.95 |
| CKB | interacts_with | gene | 0.80 |
| P38 | activates | gene | 0.60 |
| IL1B | activates | gene | 0.60 |
| PRDX1 | activates | gene | 0.60 |
| TRAF6 | activates | gene | 0.60 |
| CHUK | activates | gene | 0.60 |
| PARKIN | inhibits | gene | 0.60 |
| SLC7A11 | associated_with | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| MAPK14 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| MAP3K7 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ECSIT | activates | gene | 0.60 |
| IKBKB | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| TSC1 | contributes_to | gene | 0.60 |
| CREB3 | contributes_to | gene | 0.60 |
| ATP1A1 | contributes_to | gene | 0.60 |
| COX5A | contributes_to | gene | 0.60 |
| TAK1 | activates | gene | 0.60 |
| RELA | activates | gene | 0.60 |
| MYC | inhibits | gene | 0.60 |
| CRYAB | interacts_with | gene | 0.60 |
| NOS1 | associated_with | gene | 0.60 |
| IL6 | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| SERPINA3 | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| CD44 | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CRYAB | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| MAPK1 | associated_with | gene | 0.60 |
| MMP1 | associated_with | gene | 0.60 |
| MT1A | associated_with | gene | 0.60 |
| NFE2L2 | associated_with | gene | 0.60 |
| MMP9 | expressed_in | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| G6PD | associated_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| NF-KB | activates | gene | 0.60 |
| NFKB | activates | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||