gene

PRDX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

214Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

PRDX6 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, contributes to. Associated with Aging, Als, Cancer. Connected to 100 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPRDX6
Full NamePeroxiredoxin 6
Chromosome1q25.1
Functionis a unique member of the peroxiredoxin family with distinctive dual enzyme activities that set it apart from other peroxiredoxins.
Primary ExpressionBrain, Liver, Lung, Heart, Kidney
Molecular Weight25 kDa
Amino Acids224 aa
Exons9
PathwaysMitophagy
UniProt IDP30041
NCBI Gene ID9588
Ensembl IDENSG00000119004
OMIM603351
GeneCardsPRDX6
Human Protein AtlasPRDX6
Associated DiseasesAging, Als, Cancer, Cardiovascular, Ms, Tumor
InteractionsMAPK14, BECN1, TNF, ECSIT, MAP3K7, TLR4
KG Connections214 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PRDX6 — AlphaFold P30041 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

prdx6

gene · 2449 words

CHUK — IKK Alpha (IκB Kinase Alpha)

gene · 1969 words

ECSIT — Evolutionarily Conserved Signaling Intermediate in Toll Pathways

gene · 1906 words

Peroxiredoxin 5 (PRDX5)

protein · 1343 words

Oxidative Stress Therapeutics Investment Landscape

investment · 1218 words

Oxidative Stress Therapeutics: Investment Landscape Analysis

investment · 1134 words

Pathway Diagram

graph TD
    PRDX6["PRDX6"]
    PRDX6 -->|"activates"| Cancer["Cancer"]
    PRDX6 -->|"inhibits"| Hepatitis["Hepatitis"]
    PRDX6 -->|"inhibits"| Carcinoma["Carcinoma"]
    PRDX6 -->|"inhibits"| Als["Als"]
    PRDX6 -->|"inhibits"| Cirrhosis["Cirrhosis"]
    PRDX6 -->|"inhibits"| Ms["Ms"]
    PRDX6 -->|"contributes to"| Tumor["Tumor"]
    PRDX6 -->|"activates"| MAPK14["MAPK14"]
    PRDX6 -->|"activates"| BECN1["BECN1"]
    PRDX6 -->|"activates"| TNF["TNF"]
    CKB["CKB"] -->|"interacts"| PRDX6
    P38["P38"] -->|"activates"| PRDX6
    MAP1LC3["MAP1LC3"] -->|"activates"| PRDX6
    IL1B["IL1B"] -->|"activates"| PRDX6
    PRDX1["PRDX1"] -->|"activates"| PRDX6
    TRAF6["TRAF6"] -->|"activates"| PRDX6
    CHUK["CHUK"] -->|"activates"| PRDX6
    PARKIN["PARKIN"] -->|"inhibits"| PRDX6
    TLR4["TLR4"] -->|"activates"| PRDX6
    UBIQUITIN["UBIQUITIN"] -->|"activates"| PRDX6

Outgoing (135)

TargetRelationTypeStr
Neuroinflammationassociated_withprocess0.95
PARKINinteracts_withprotein0.90
mitophagyinhibitsprocess0.90
M1 Microgliaregulatesphenotype0.85
Astrocytesmodulatescell_type0.80

Incoming (79)

SourceRelationTypeStr
MIZ1binds_toprotein0.95
CKBinteracts_withgene0.80
P38activatesgene0.60
IL1Bactivatesgene0.60
PRDX1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found