gene

SOD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

763Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

SOD2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 454 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSOD2
Full NameSuperoxide Dismutase 2, Mitochondrial
Chromosome6q25.3
FunctionSOD2 provides essential mitochondrial antioxidant defense
Molecular Weight22.3 kDa
Amino Acids222 aa
Exons5
PathwaysAkt, Apoptosis, Mapk, Mitochondrial Function, Mtor
NCBI Gene ID6648
Ensembl IDENSG00000112096
OMIM147460
GeneCardsSOD2
Human Protein AtlasSOD2
ApproachStrategy
SOD mimeticsEukarion, MitoQ
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/CompoundsLactiplantibacillus plantarum FRT4, resveratrol, berberine, RESVERATROL, BERBERINE
InteractionsFOXO1, ERK1, NOX4, SOD1, SOD3, SIRT3
KG Connections763 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SOD2 Gene

gene · 766 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

NRF2 Oxidative Stress Pathway

mechanism · 5315 words

Sulforaphane and Nrf2 Activation for Neuroprotection

therapeutic · 4477 words

dimethyl-fumarate-nrf2-ad-nct06850597

clinical_trial · 4373 words

vitamin-d-therapy-neurodegeneration

therapeutic · 4119 words

Pathway Diagram

graph TD
    SOD2["SOD2"] -->|"Degrades"| superoxide_anion["superoxide anion"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Cancer["Cancer"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Ms["Ms"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Parkinson["Parkinson"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Inflammation["Inflammation"]
    SOD2["SOD2"] -->|"Therapeutic Target"| Diabetes["Diabetes"]
    SOD2["SOD2"] -->|"Inhibits"| Cardiovascular["Cardiovascular"]
    SOD2["SOD2"] -->|"Inhibits"| Als["Als"]
    Lactiplantibacillus_plantarum_["Lactiplantibacillus plantarum FRT4"] -->|"Activates"| SOD2["SOD2"]
    FOXO1["FOXO1"] -->|"Activates"| SOD2["SOD2"]
    MET["MET"] -->|"Therapeutic Target"| SOD2["SOD2"]
    TPM2["TPM2"] -->|"Therapeutic Target"| SOD2["SOD2"]
    PANX1["PANX1"] -->|"Regulates"| SOD2["SOD2"]
    style SOD2 fill:#8d4900,color:#e0e0e0
    style superoxide_anion fill:#607D8B,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style Diabetes fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Lactiplantibacillus_plantarum_ fill:#00838f,color:#e0e0e0
    style FOXO1 fill:#8d4900,color:#e0e0e0
    style MET fill:#8d4900,color:#e0e0e0
    style TPM2 fill:#8d4900,color:#e0e0e0
    style PANX1 fill:#8d4900,color:#e0e0e0

Outgoing (444)

TargetRelationTypeStr
superoxide anioninhibitsphenotype0.95
mitochondrial reactive oxygen speciesinhibitsprocess0.94
Inflammationactivatesdisease0.75
Agingactivatesdisease0.75
Alsactivatesdisease0.75

Incoming (319)

SourceRelationTypeStr
MNdownregulatescompound0.95
Sirt3regulatesprotein0.92
URG7upregulatesenzyme0.92
FOXO1upregulatesgene0.90
STAT3regulatesgene0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found