SciDEX — NAD+ metabolism

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAD+ metabolism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Outgoing (5)

Target	Relation	Type	Str
cancer	drives	disease	0.85
immune system	regulates	pathway	0.85
aging	regulates	process	0.85

Incoming (63)

Source	Relation	Type	Str
SIRT1	participates_in	gene	0.85
nicotinamide	modulates	drug	0.85
neurodegeneration	involves	disease	0.85
NAD	participates_in	gene	0.85
neurons	active_in	cell_type	0.85
NADH	participates_in	gene	0.85
DAM microglia	active_in	cell_type	0.85
AMPK	participates_in	gene	0.85
ATP	participates_in	gene	0.85
CD38	regulates	gene	0.80
resveratrol	modulates	drug	0.75
NAMPT	participates_in	gene	0.75
APP	participates_in	gene	0.75
PARP1	participates_in	gene	0.75
SIRT3	participates_in	gene	0.75
NRF1	participates_in	gene	0.75
TFAM	participates_in	gene	0.75
FOXO3	participates_in	gene	0.75
PS1	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
DNA	participates_in	gene	0.75
Alzheimer's disease	involves	disease	0.75
CLOCK	participates_in	gene	0.65
BMAL1	participates_in	gene	0.65
neuroinflammation	involves	disease	0.65
SIRT6	participates_in	gene	0.65
metformin	modulates	drug	0.65
FOXO	participates_in	gene	0.65
microglia	active_in	cell_type	0.65
Parkinson's disease	involves	disease	0.65
CD38	participates_in	gene	0.55
STX17	participates_in	gene	0.55
PINK1	participates_in	gene	0.55
excitatory neurons	active_in	cell_type	0.55
COX5A	participates_in	gene	0.55
RORB	participates_in	gene	0.55
inhibitory neurons	active_in	cell_type	0.55
TFEB	participates_in	gene	0.55
PPARA	participates_in	gene	0.55
SREBF1	participates_in	gene	0.55
PPARGC1A	participates_in	gene	0.55
HDAC3	participates_in	gene	0.55
ATG5	participates_in	gene	0.55
LC3	participates_in	gene	0.55
ATG7	participates_in	gene	0.55
HK2	participates_in	gene	0.55
TNF	participates_in	gene	0.55
SIRT7	participates_in	gene	0.55
NRF2	participates_in	gene	0.55
APOE4	participates_in	gene	0.55

NAD+ metabolism

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Outgoing (5)

Incoming (63)

Targeting Hypotheses (0)

Mentioning Analyses (1)

Senolytic therapy for age-related neurodegeneration

Related Papers (0)

NAD+ metabolism

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Epigenetic Alterations in Alzheimer's Disease

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease

uni-pittsburgh

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

DNA Damage Response Impairment Pathway

Metabolomic Alterations in PSP

NAD+ Precursors for Neurodegeneration

Cellular Senescence in Neurodegeneration

Quinolinic Acid Neurotoxicity in Neurodegeneration

Wallerian Degeneration

Mitophagy Pathway in Neurodegeneration

AD Therapeutic Approaches Ranked Scorecard

chromatin-remodeling-neurodegeneration

Cockayne Syndrome

Sirtuin Signaling in Parkinson's Disease

Outgoing (5)

Incoming (63)

Targeting Hypotheses (0)

Mentioning Analyses (1)

Senolytic therapy for age-related neurodegeneration

Related Papers (0)