protein 2,062 words KG: CHCHD2 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

CHCHD2 Protein

🔬 Protein Info
Gene SymbolCHCHD2
Full NameCHCHD2
Chromosome7p13
Protein FamilyCoiled-Coil-Helix-Coiled-Coil-Helix (CHCHD) domain proteins
Protein TypeProtein
Functionis a small mitochondrial protein that plays critical roles in mitochondrial function, cellular metabolism, and Parkinson's disease (PD) pathogenesis.
Primary Expressiondopaminergic neurons of the substantia nigra pars compacta, explaining the selective vulnerability of these neurons in PD
Molecular Weight26 kDa
Amino Acids182 aa
PathwaysMitophagy
UniProt IDSearch UniProt
GeneCardsCHCHD2
Human Protein AtlasCHCHD2
Associated DiseasesALS, Aging, Amyotrophic Lateral Sclerosis, Dementia, Kii ALS/PDC
InteractionsGPX4, LRRK2, SNCA, TDP43, FBXO7, JNK
KG Connections194 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (2)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (5)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: expressed_in
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: implicated_in
Astrocytes
entity · KG edge: implicated_in
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

CHCHD2 inhibits GPX4
CHCHD2 therapeutic_target SNCA
CHCHD2 regulates PRKN
CHCHD2 regulates PINK1
CHCHD2 regulates PTEN
CHCHD2 regulates PARKIN
CHCHD2 therapeutic_target LRRK2
CHCHD2 associated_with Kii ALS/PDC
CHCHD2 regulates Mitochondrial Morphology
CHCHD2 regulates Mitochondrial Metabolism