| Gene Symbol | COX8A |
| Full Name | Cytochrome c Oxidase Subunit 8A |
| Chromosome | 11q13.1 |
| Function | is a nuclear-encoded mitochondrial protein that serves as a structural subunit of cytochrome c oxidase (Complex IV) of the electron transport chain. |
| Molecular Weight | 7.8 kDa |
| Amino Acids | 69 aa |
| UniProt ID | [P10176](https://www.uniprot.org/uniprot/P10176) |
| Ensembl ID | ENSG00000160789 |
| GeneCards | COX8A |
| Human Protein Atlas | COX8A |
| Assembly factor | COX8A is required for proper Complex IV assembly and stability |
| Dimer formation | COX8A participates in Complex IV dimer formation, which is important for cristae organization |
| Proton channel | Contributes to the proton exit channel of the enzyme |
| High expression | Heart, skeletal muscle, brain (especially cortex and hippocampus) |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | NDUFA12, NDUFA5, NDUFS1, NDUFS4, COX15, COX4I1 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |