protein

CUL3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CUL3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

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Summary

The most neuroscience-relevant CRL3 complex is CRL3^KEAP1, which constitutively ubiquitinates NRF2, the master regulator of antioxidant gene expression.

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🔬 Protein Info

Gene Symbol	CUL3PROTEIN
Full Name	Cullin-3
Protein Family	Cullin family (CUL1-7, PARC)
Function	The most neuroscience-relevant CRL3 complex is CRL3^KEAP1, which constitutively ubiquitinates NRF2, the master regulator of antioxidant gene expression.
Amino Acids	768 aa
UniProt ID	Q13618
GeneCards	CUL3PROTEIN
Human Protein Atlas	CUL3PROTEIN
4-helix bundle (4HB, residues 385-455)	Connecting region between N- and C-terminal domains
Associated Diseases	ALS
Interactions	AKT, APOPTOSIS, AUTOPHAGY, BACH1, BCL2, BECN1
KG Connections	179 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CUL3PROTEIN — AlphaFold Q13618 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cullin-3 — Protein

protein · 823 words

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Pathway Diagram

graph TD
    CUL3PROTEIN["CUL3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CUL3PROTEIN -->|"implicated_in"| neurodegeneration
    style CUL3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CUL3PROTEIN in their description or question text

No additional research found