BACH1

Understanding Entity Pages

This page aggregates everything SciDEX knows about BACH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

BACH1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 114 entities in the SciDEX knowledge graph.

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graph TD
    BACH1["<b>BACH1</b>"]
    LDLR["LDLR"]
    BACH1 -->|"inhibits"| LDLR
    Cancer{"Cancer"}
    BACH1 -->|"activates"| Cancer
    Als{"Als"}
    BACH1 -->|"activates"| Als
    BACH1 -->|"regulates"| Cancer
    Aging{"Aging"}
    BACH1 -->|"activates"| Aging
    Neurodegeneration{"Neurodegeneration"}
    BACH1 -->|"activates"| Neurodegeneration
    Inflammation{"Inflammation"}
    BACH1 -->|"activates"| Inflammation
    BACH1 -->|"therapeutic target"| Als
    Tumor{"Tumor"}
    BACH1 -->|"inhibits"| Tumor
    Glioblastoma{"Glioblastoma"}
    BACH1 -->|"therapeutic target"| Glioblastoma
    ALS{"ALS"}
    BACH1 -->|"activates"| ALS
    Pi3K(["Pi3K"])
    BACH1 -->|"activates"| Pi3K
    PKC["PKC"]
    PKC -->|"activates"| BACH1
    FYN["FYN"]
    FYN -->|"activates"| BACH1
    KEAP1["KEAP1"]
    KEAP1 -->|"activates"| BACH1
    CUL3["CUL3"]
    CUL3 -->|"activates"| BACH1
    NRF2["NRF2"]
    NRF2 -->|"activates"| BACH1
    PI3K["PI3K"]
    PI3K -->|"activates"| BACH1
    GENES["GENES"]
    GENES -->|"activates"| BACH1
    AKT["AKT"]
    AKT -->|"regulates"| BACH1
    P62["P62"]
    P62 -->|"activates"| BACH1
    ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
    ANTIOXIDANT_GENES -->|"activates"| BACH1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| BACH1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| BACH1
    style BACH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0