protein

CYP27A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP27A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
0Hypotheses
0Analyses
17Outgoing
7Incoming

Summary

CYP27A1 is a protein involved in neurodegeneration research. Key relationships include: contributes to, biomarker for, implicated in. Associated with Als, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolCYP27A1
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmultiple tissues:
Molecular Weight60 kDa
Amino Acids503 aa
PathwaysLipid Metabolism
Ensembl IDENSG00000135929
GeneCardsCYP27A1
Human Protein AtlasCYP27A1
Cholesterol 27-HydroxylationCatalyzes the first step in the alternative (27-hydroxyl) pathway of bile acid synthesis, converting cholesterol to 27-hydroxycholesterol (27-HC)[@bjorkhem2013]
Bile Acid SynthesisConverts cholesterol to cholestenoic acid derivatives that are further processed to chenodeoxycholic acid and cholic acid
Oxysterol ProductionGenerates 27-hydroxycholesterol, a potent oxysterol that regulates LXR (Liver X Receptor) signaling and cholesterol homeostasis
Vitamin D MetabolismParticipates in the side-chain oxidation of vitamin D metabolites
Neurosteroid SynthesisMay contribute to neuroactive steroid formation in the brain
Associated Diseasesneurodegeneration
InteractionsCYP46A1, CYP7B1
KG Connections24 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

CYP27A1 Gene

gene · 706 words

Vitamin D Signaling Pathway in Neurodegeneration

mechanism · 4520 words

Lipid Metabolism Dysfunction Comparison — AD/PD/ALS/FTD/HD

mechanism · 3831 words

Lipid Metabolism Dysregulation in Neurodegeneration

mechanism · 3499 words

Cerebrotendinous Xanthomatosis (CTX)

disease · 2271 words

CYP27B1 — Vitamin D 1-alpha Hydroxylase

gene · 1954 words

Pathway Diagram

graph TD
    CYP27A1["<b>CYP27A1</b>"]
    Ms{"Ms"}
    CYP27A1 -->|"biomarker for"| Ms
    Als{"Als"}
    CYP27A1 -->|"contributes to"| Als
    CYP27A1 -->|"contributes to"| Ms
    DDIT3["DDIT3"]
    CYP27A1 -->|"contributes to"| DDIT3
    KDM5B["KDM5B"]
    CYP27A1 -->|"contributes to"| KDM5B
    Lipid_Metabolism(["Lipid Metabolism"])
    CYP27A1 -->|"activates"| Lipid_Metabolism
    neurodegeneration["neurodegeneration"]
    CYP27A1 -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"biomarker for"| CYP27A1
    CEBPD["CEBPD"]
    CEBPD -->|"biomarker for"| CYP27A1
    CTSD["CTSD"]
    CTSD -->|"biomarker for"| CYP27A1
    style CYP27A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

TargetRelationTypeStr
Msbiomarker_fordisease0.65
Alscontributes_todisease0.65
Mscontributes_todisease0.65
Alsregulatesdisease0.65
ALSregulatesdisease0.65

Incoming (7)

SourceRelationTypeStr
CD4biomarker_forgene0.60
CEBPDbiomarker_forgene0.60
CTSDbiomarker_forgene0.60
CYP46A1regulatesgene0.60
MITOCHONDRIAexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found