Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYP27A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CYP27A1 is a protein involved in neurodegeneration research. Key relationships include: contributes to, biomarker for, implicated in. Associated with Als, Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | CYP27A1 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | multiple tissues: |
| Molecular Weight | 60 kDa |
| Amino Acids | 503 aa |
| Pathways | Lipid Metabolism |
| Ensembl ID | ENSG00000135929 |
| GeneCards | CYP27A1 |
| Human Protein Atlas | CYP27A1 |
| Cholesterol 27-Hydroxylation | Catalyzes the first step in the alternative (27-hydroxyl) pathway of bile acid synthesis, converting cholesterol to 27-hydroxycholesterol (27-HC)[@bjorkhem2013] |
| Bile Acid Synthesis | Converts cholesterol to cholestenoic acid derivatives that are further processed to chenodeoxycholic acid and cholic acid |
| Oxysterol Production | Generates 27-hydroxycholesterol, a potent oxysterol that regulates LXR (Liver X Receptor) signaling and cholesterol homeostasis |
| Vitamin D Metabolism | Participates in the side-chain oxidation of vitamin D metabolites |
| Neurosteroid Synthesis | May contribute to neuroactive steroid formation in the brain |
| Associated Diseases | neurodegeneration |
| Interactions | CYP46A1, CYP7B1 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CYP27A1["<b>CYP27A1</b>"]
Ms{"Ms"}
CYP27A1 -->|"biomarker for"| Ms
Als{"Als"}
CYP27A1 -->|"contributes to"| Als
CYP27A1 -->|"contributes to"| Ms
DDIT3["DDIT3"]
CYP27A1 -->|"contributes to"| DDIT3
KDM5B["KDM5B"]
CYP27A1 -->|"contributes to"| KDM5B
Lipid_Metabolism(["Lipid Metabolism"])
CYP27A1 -->|"activates"| Lipid_Metabolism
neurodegeneration["neurodegeneration"]
CYP27A1 -->|"implicated in"| neurodegeneration
CD4["CD4"]
CD4 -->|"biomarker for"| CYP27A1
CEBPD["CEBPD"]
CEBPD -->|"biomarker for"| CYP27A1
CTSD["CTSD"]
CTSD -->|"biomarker for"| CYP27A1
style CYP27A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | biomarker_for | disease | 0.65 |
| Als | contributes_to | disease | 0.65 |
| Ms | contributes_to | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| DDIT3 | contributes_to | gene | 0.60 |
| KDM5B | contributes_to | gene | 0.60 |
| CYP46A1 | interacts_with | gene | 0.60 |
| CYP7B1 | interacts_with | gene | 0.60 |
| CYP7B1 | expressed_in | gene | 0.60 |
| CYP46A1 | regulates | gene | 0.60 |
| CYP7B1 | regulates | gene | 0.60 |
| Lipid Metabolism | activates | pathway | 0.60 |
| MITOCHONDRIA | expressed_in | gene | 0.60 |
| Cholesterol | expressed_in | pathway | 0.60 |
| CYP11A1 | regulates | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||