gene

CYP11A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP11A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

Summary

Page for CYP11A1 Gene (CHASER) - the rate-limiting enzyme in steroidogenesis

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🧬 Gene Info

Gene Symbol	CYP11A1
Aliases	CHASER, Cholesterol Side-Chain Cleavage Enzyme
Function	Cyp11A1 Protein (Cholesterol Side Chain Cleavage Enzyme) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, fu...
Subcellular Localization	- functional domains specific to its protein family - potential regulatory regio
Molecular Weight	56 kDa
Pathways	Autophagy, Ubiquitin-Proteasome, epigenetic regulation, oxidative stress response, autophagy pathway
GeneCards	CYP11A1
Human Protein Atlas	CYP11A1
Interactions	TUBB3, HDAC6, CDC42, MAP3K5, CASP3, GJA1
KG Connections	93 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CYP11A1["<b>CYP11A1</b>"]
    TUBB3["TUBB3"]
    CYP11A1 -->|"activates"| TUBB3
    HDAC6["HDAC6"]
    CYP11A1 -->|"activates"| HDAC6
    CDC42["CDC42"]
    CYP11A1 -->|"activates"| CDC42
    MAP3K5["MAP3K5"]
    CYP11A1 -->|"activates"| MAP3K5
    CASP3["CASP3"]
    CYP11A1 -->|"activates"| CASP3
    GJA1["GJA1"]
    CYP11A1 -->|"activates"| GJA1
    VIMENTIN["VIMENTIN"]
    CYP11A1 -->|"activates"| VIMENTIN
    LAMP1["LAMP1"]
    CYP11A1 -->|"activates"| LAMP1
    UBIQUITIN["UBIQUITIN"]
    CYP11A1 -->|"activates"| UBIQUITIN
    RAC1["RAC1"]
    CYP11A1 -->|"activates"| RAC1
    OCCLUDIN["OCCLUDIN"]
    CYP11A1 -->|"activates"| OCCLUDIN
    TUBULIN["TUBULIN"]
    CYP11A1 -->|"activates"| TUBULIN
    Stem_Cell["Stem Cell"]
    CYP11A1 -->|"activates"| Stem_Cell
    TJP1["TJP1"]
    CYP11A1 -->|"activates"| TJP1
    SCIN["SCIN"]
    CYP11A1 -->|"activates"| SCIN
    Cell_Division["Cell Division"]
    CYP11A1 -->|"activates"| Cell_Division
    Receptor_Tyrosine_Kinase["Receptor Tyrosine Kinase"]
    CYP11A1 -->|"activates"| Receptor_Tyrosine_Kinase
    Cholesterol["Cholesterol"]
    CYP11A1 -->|"expressed in"| Cholesterol
    ACTB["ACTB"]
    ACTB -->|"activates"| CYP11A1
    ATG14["ATG14"]
    ATG14 -->|"activates"| CYP11A1
    Autophagy["Autophagy"]
    Autophagy -->|"activates"| CYP11A1
    OCLN["OCLN"]
    OCLN -->|"activates"| CYP11A1
    H2AX["H2AX"]
    H2AX -->|"activates"| CYP11A1
    UVRAG["UVRAG"]
    UVRAG -->|"activates"| CYP11A1
    BECN1["BECN1"]
    BECN1 -->|"activates"| CYP11A1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| CYP11A1
    STK11["STK11"]
    STK11 -->|"activates"| CYP11A1
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"activates"| CYP11A1
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"activates"| CYP11A1
    GAPDH["GAPDH"]
    GAPDH -->|"activates"| CYP11A1

Outgoing (61)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Autophagy	associated_with	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
CYP46A1	regulates	gene	0.60
CYP27A1	regulates	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
HDAC6	regulates	gene	0.60
ACTB	associated_with	gene	0.60
TJP1	regulates	gene	0.60
SCIN	regulates	gene	0.60
CASP3	associated_with	gene	0.60
TUBB3	regulates	gene	0.60
LAMP1	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
UVRAG	regulates	gene	0.60
VIMENTIN	regulates	gene	0.60
OCLN	regulates	gene	0.60
TUBULIN	regulates	gene	0.60
CDC42	associated_with	gene	0.60
Stem Cell	regulates	cell_type	0.60
Proteasome	regulates	protein	0.60
Caspase	associated_with	protein	0.60
Actin	associated_with	protein	0.60
P4HB	activates	gene	0.60
Fus	activates	protein	0.60
GAPDH	activates	gene	0.60
H2AX	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OCLN	activates	gene	0.60
PIK3C3	activates	gene	0.60
SQSTM1	activates	gene	0.60
STK11	activates	gene	0.60
UVRAG	activates	gene	0.60
VIM	activates	gene	0.60
WT1	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
blood-brain barrier	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
TUBB3	activates	gene	0.50
HDAC6	activates	gene	0.50
CDC42	activates	gene	0.50
MAP3K5	activates	gene	0.50
CASP3	activates	gene	0.50
GJA1	activates	gene	0.50
VIMENTIN	activates	protein	0.50

Incoming (32)

Source	Relation	Type	Str
BECN1	associated_with	gene	0.60
STK11	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
GJA1	associated_with	gene	0.60
ATG14	associated_with	gene	0.60
VIM	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
H2AX	associated_with	gene	0.60
RAC1	regulates	gene	0.60
WT1	regulates	gene	0.60
GAPDH	associated_with	gene	0.60
MAP3K5	regulates	gene	0.60
CYP46A1	regulates	gene	0.60
CYP27A1	regulates	gene	0.60
RNA	activates	gene	0.60
AR	activates	gene	0.60
CASP3	activates	gene	0.60
CDC42	activates	gene	0.60
ACTB	activates	gene	0.50
ATG14	activates	gene	0.50
Autophagy	activates	process	0.50
OCLN	activates	gene	0.50
H2AX	activates	gene	0.50
UVRAG	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
STK11	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
PIK3C3	activates	gene	0.50
GAPDH	activates	gene	0.50
MITOCHONDRIA	expressed_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CYP11A1

Understanding Entity Pages

Summary

Wiki Pages (6)

HPA Axis Neurons in Neurodegeneration

CYP11A1 Gene - Cholesterol Side-Chain Cleavage Enzyme

Allopregnanolone Regenerative Therapeutic (NCT04838301)

Progesterone Signaling Pathway in Neurodegeneration