Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DAXX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DAXX is a gene implicated in neurodegeneration research. Key relationships include: treats, regulates, implicated in. Associated with Als, Alzheimer, Breast Cancer. Connected to 13 entities in the SciDEX knowledge graph.
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| Gene Symbol | DAXX |
| Full Name | Death-Domain Associated Protein |
| Chromosome | 6p21.3. |
| Function | is a multifunctional protein encoded by the DAXX gene located on chromosome 6p21. |
| Amino Acids | 740 aa |
| UniProt ID | Q9UER7 |
| NCBI Gene ID | 1616 |
| Ensembl ID | ENSG00000204264 |
| OMIM | 603186 |
| GeneCards | DAXX |
| Human Protein Atlas | DAXX |
| Transcriptional regulator | Modulates gene expression through histone modification |
| Associated Diseases | neurodegeneration |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DAXX["DAXX"]
Cardiovascular["Cardiovascular"]
DAXX -->|"treats"| Cardiovascular
Cancer["Cancer"]
DAXX -->|"treats"| Cancer
Als["Als"]
DAXX -->|"treats"| Als
Breast_Cancer["Breast Cancer"]
DAXX -->|"treats"| Breast_Cancer
Alzheimer["Alzheimer"]
DAXX -->|"treats"| Alzheimer
Alzheimer["Alzheimer"]
DAXX -->|"therapeutic target"| Alzheimer
Als["Als"]
DAXX -->|"therapeutic target"| Als
Cancer["Cancer"]
DAXX -->|"therapeutic target"| Cancer
BDNF["BDNF"]
DAXX -->|"regulates"| BDNF
ALZHEIMER["ALZHEIMER"]
DAXX -->|"treats"| ALZHEIMER
AMYLOID["AMYLOID"]
DAXX -->|"regulates"| AMYLOID
CANCER["CANCER"]
DAXX -->|"treats"| CANCER
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
DAXX -->|"treats"| ALZHEIMER_S_DISEASE
APP["APP"]
DAXX -->|"regulates"| APP
APOE["APOE"]
DAXX -->|"regulates"| APOE
Neuron["Neuron"]
DAXX -->|"regulates"| Neuron
AMYLOID["AMYLOID"]
AMYLOID -->|"regulates"| DAXX
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"therapeutic target"| DAXX
APP["APP"]
APP -->|"regulates"| DAXX
BDNF["BDNF"]
BDNF -->|"regulates"| DAXX
APOE["APOE"]
APOE -->|"regulates"| DAXX
neurodegeneration["neurodegeneration"]
DAXX -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Alzheimer | treats | disease | 0.65 |
| Cardiovascular | treats | disease | 0.65 |
| Cancer | treats | disease | 0.65 |
| Als | treats | disease | 0.65 |
| Breast Cancer | treats | disease | 0.65 |
| AMYLOID | regulates | gene | 0.60 |
| CANCER | treats | gene | 0.60 |
| ALZHEIMER'S DISEASE | treats | gene | 0.60 |
| ALZHEIMER | treats | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| APP | regulates | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DAXX in their description or question text
No additional research found