protein

EPAS1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPAS1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

The basic helix-loop-helix (bHLH) domain serves as the primary DNA-binding module. This domain recognizes and binds to the hypoxia response element (HRE) with the consensus sequence 5'-RCGTG-3' found in the promoters of target genes.

View on Wiki →

🔬 Protein Info

Gene Symbol	EPAS1
Full Name	Endothelial PAS Domain Protein 1
Aliases	HIF-2α
Chromosome	2p21
Protein Family	bHLH-PAS transcription factor family
Protein Type	Transcription Factor
Function	is a transcription factor that serves as the master regulator of cellular responses to hypoxia.
Primary Expression	Highest in endothelial cells, neurons, cardiomyocytes, type II pneumocytes
Subcellular Localization	Nucleus and cytoplasm (-regulated by oxygen)
Molecular Weight	~96-118 kDa (depending on post-translational modifications)
Amino Acids	870 aa
Exons	16
Pathways	Apoptosis, MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway
UniProt ID	Q9Y5Q3
NCBI Gene ID	2034
Ensembl ID	ENSG00000177640
OMIM	603349
GeneCards	EPAS1
Human Protein Atlas	EPAS1
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Interactions	MIRO1, CTSD, RB1, EIF2AK3, PRKN, BCL2L11
KG Connections	495 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPAS1PROTEIN — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

epas1-protein

protein · 2900 words

→

Pathway Diagram

graph TD
    EPAS1PROTEIN["EPAS1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    EPAS1PROTEIN -->|"implicated_in"| neurodegeneration
    style EPAS1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity