protein

ERLIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERLIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections
0Hypotheses
0Analyses
9Outgoing
1Incoming

Summary

ERLIN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolERLIN1
Full NameERLIN1
AliasesErlin-1
Protein TypeGene
Functionis an SPFH-domain protein enriched in cholesterol-rich ER subdomains.
Molecular Weight400 kDa
Amino Acids299 aa
PathwaysSignaling:** Modulates various signaling pathways
NCBI Gene IDSearch NCBI
GeneCardsERLIN1
Human Protein AtlasERLIN1
Associated DiseasesDemyelination, Ms, Neurodegeneration
InteractionsBECN1
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

ERLIN1 Gene

gene · 861 words

Demyelination

mechanism · 3212 words

ERLIN1 Protein (Erlin-1)

protein · 739 words

ERLIN2 — ER Lipid Raft Associated 2

gene · 583 words

ERLIN2 Protein

protein · 575 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    ERLIN1["<b>ERLIN1</b>"]
    TREM2["TREM2"]
    ERLIN1 -->|"associated with"| TREM2
    OxPC["OxPC"]
    ERLIN1 -->|"associated with"| OxPC
    Neurodegeneration["Neurodegeneration"]
    ERLIN1 -->|"associated with"| Neurodegeneration
    Demyelination["Demyelination"]
    ERLIN1 -->|"associated with"| Demyelination
    Microglia["Microglia"]
    ERLIN1 -->|"associated with"| Microglia
    Ms{"Ms"}
    ERLIN1 -->|"associated with"| Ms
    AUTOPHAGY["AUTOPHAGY"]
    ERLIN1 -->|"associated with"| AUTOPHAGY
    BECN1["BECN1"]
    ERLIN1 -->|"interacts with"| BECN1
    Autophagy(["Autophagy"])
    ERLIN1 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    ERLIN1 -->|"implicated in"| neurodegeneration
    AMBRA1["AMBRA1"]
    AMBRA1 -->|"associated with"| ERLIN1
    style ERLIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

TargetRelationTypeStr
TREM2associated_withgene0.80
OxPCassociated_withchemical0.80
Demyelinationassociated_withphenotype0.80
Neurodegenerationassociated_withphenotype0.80
Microgliaassociated_withcell_type0.80

Incoming (1)

SourceRelationTypeStr
AMBRA1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found