Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ERLIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ERLIN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Ms. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | ERLIN1 |
| Full Name | ERLIN1 |
| Aliases | Erlin-1 |
| Protein Type | Gene |
| Function | is an SPFH-domain protein enriched in cholesterol-rich ER subdomains. |
| Molecular Weight | 400 kDa |
| Amino Acids | 299 aa |
| Pathways | Signaling:** Modulates various signaling pathways |
| NCBI Gene ID | Search NCBI |
| GeneCards | ERLIN1 |
| Human Protein Atlas | ERLIN1 |
| Associated Diseases | Demyelination, Ms, Neurodegeneration |
| Interactions | BECN1 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
ERLIN1["<b>ERLIN1</b>"]
TREM2["TREM2"]
ERLIN1 -->|"associated with"| TREM2
OxPC["OxPC"]
ERLIN1 -->|"associated with"| OxPC
Neurodegeneration["Neurodegeneration"]
ERLIN1 -->|"associated with"| Neurodegeneration
Demyelination["Demyelination"]
ERLIN1 -->|"associated with"| Demyelination
Microglia["Microglia"]
ERLIN1 -->|"associated with"| Microglia
Ms{"Ms"}
ERLIN1 -->|"associated with"| Ms
AUTOPHAGY["AUTOPHAGY"]
ERLIN1 -->|"associated with"| AUTOPHAGY
BECN1["BECN1"]
ERLIN1 -->|"interacts with"| BECN1
Autophagy(["Autophagy"])
ERLIN1 -->|"associated with"| Autophagy
neurodegeneration["neurodegeneration"]
ERLIN1 -->|"implicated in"| neurodegeneration
AMBRA1["AMBRA1"]
AMBRA1 -->|"associated with"| ERLIN1
style ERLIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TREM2 | associated_with | gene | 0.80 |
| OxPC | associated_with | chemical | 0.80 |
| Demyelination | associated_with | phenotype | 0.80 |
| Neurodegeneration | associated_with | phenotype | 0.80 |
| Microglia | associated_with | cell_type | 0.80 |
| Ms | associated_with | disease | 0.65 |
| BECN1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMBRA1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||