gene 861 words KG: ERLIN1 2026-03-21
kind:genesection:genesstate:published
Contents

ERLIN1 Gene

🧬 Gene Info
Gene SymbolERLIN1
Full NameERLIN1
AliasesErlin-1
Protein TypeGene
Functionis an SPFH-domain protein enriched in cholesterol-rich ER subdomains.
Molecular Weight400 kDa
Amino Acids299 aa
PathwaysSignaling:** Modulates various signaling pathways
NCBI Gene IDSearch NCBI
GeneCardsERLIN1
Human Protein AtlasERLIN1
Associated DiseasesDemyelination, Ms, Neurodegeneration
InteractionsBECN1
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Demyelination
mechanism · KG edge: associated_with
BECN1 Gene
gene · KG edge: interacts_with
AMBRA1 Gene
gene · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: associated_with

Knowledge Graph (10 edges)

ERLIN1 interacts_with BECN1
ERLIN1 associated_with TREM2
ERLIN1 associated_with OxPC
ERLIN1 associated_with Demyelination
ERLIN1 associated_with AUTOPHAGY
ERLIN1 associated_with Ms
ERLIN1 associated_with Autophagy
ERLIN1 associated_with Neurodegeneration
ERLIN1 associated_with Microglia
AMBRA1 associated_with ERLIN1