Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FAN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FAN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Huntington, Ms. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | FAN1 |
| Full Name | FANCD2 Associated Nuclease 1 |
| Chromosome | 15q13.1-q13.3 |
| Function | is a DNA repair nuclease that plays a critical role in interstrand crosslink repair |
| Primary Expression | peripheral tissues |
| Molecular Weight | 86 kDa |
| UniProt ID | Q8IY92 (FAN1) |
| NCBI Gene ID | 22919 |
| Ensembl ID | ENSG00000101391 |
| OMIM | 613375 |
| GeneCards | FAN1 |
| Human Protein Atlas | FAN1 |
| Approach | Rationale |
| Gene therapy | Restore FAN1 function |
| Small molecule enhancers | Boost nuclease activity |
| Associated Diseases | Als, Huntington, Ms |
| Interactions | HTT, MSH3, PMS2, DNA |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FAN1["<b>FAN1</b>"]
Huntington{"Huntington"}
FAN1 -->|"associated with"| Huntington
Als{"Als"}
FAN1 -->|"associated with"| Als
Ms{"Ms"}
FAN1 -->|"associated with"| Ms
DNA["DNA"]
FAN1 -->|"associated with"| DNA
HTT["HTT"]
FAN1 -->|"associated with"| HTT
PMS2["PMS2"]
FAN1 -->|"associated with"| PMS2
HUNTINGTON["HUNTINGTON"]
FAN1 -->|"associated with"| HUNTINGTON
AND["AND"]
FAN1 -->|"associated with"| AND
neurodegeneration["neurodegeneration"]
FAN1 -->|"implicated in"| neurodegeneration
MSH3["MSH3"]
MSH3 -->|"associated with"| FAN1
GENETIC_MODIFIERS["GENETIC MODIFIERS"]
GENETIC_MODIFIERS -->|"associated with"| FAN1
style FAN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Huntington | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| HTT | associated_with | gene | 0.60 |
| PMS2 | associated_with | gene | 0.60 |
| FANCD2 | regulates | gene | 0.60 |
| HTT | activates | gene | 0.60 |
| MSH3 | activates | gene | 0.60 |
| PMS2 | activates | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| FANCI | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MSH3 | associated_with | gene | 0.60 |
| GENETIC MODIFIERS | associated_with | gene | 0.60 |
| DNA | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||