protein

FAN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FAN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
12Outgoing
3Incoming

Summary

FAN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Huntington, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolFAN1
Full NameFANCD2 Associated Nuclease 1
Chromosome15q13.1-q13.3
Functionis a DNA repair nuclease that plays a critical role in interstrand crosslink repair
Primary Expressionperipheral tissues
Molecular Weight86 kDa
UniProt IDQ8IY92 (FAN1)
NCBI Gene ID22919
Ensembl IDENSG00000101391
OMIM613375
GeneCardsFAN1
Human Protein AtlasFAN1
ApproachRationale
Gene therapyRestore FAN1 function
Small molecule enhancersBoost nuclease activity
Associated DiseasesAls, Huntington, Ms
InteractionsHTT, MSH3, PMS2, DNA
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FAN1 — AlphaFold Q8IY92 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

FAN1 Gene

gene · 699 words

Huntington's Disease

disease · 4606 words

rankings

general · 4519 words

dna-damage-repair

mechanism · 3555 words

Trinucleotide Repeat Expansion Disorders

mechanism · 3379 words

FANCC Gene

gene · 2477 words

Pathway Diagram

graph TD
    FAN1["<b>FAN1</b>"]
    Huntington{"Huntington"}
    FAN1 -->|"associated with"| Huntington
    Als{"Als"}
    FAN1 -->|"associated with"| Als
    Ms{"Ms"}
    FAN1 -->|"associated with"| Ms
    DNA["DNA"]
    FAN1 -->|"associated with"| DNA
    HTT["HTT"]
    FAN1 -->|"associated with"| HTT
    PMS2["PMS2"]
    FAN1 -->|"associated with"| PMS2
    HUNTINGTON["HUNTINGTON"]
    FAN1 -->|"associated with"| HUNTINGTON
    AND["AND"]
    FAN1 -->|"associated with"| AND
    neurodegeneration["neurodegeneration"]
    FAN1 -->|"implicated in"| neurodegeneration
    MSH3["MSH3"]
    MSH3 -->|"associated with"| FAN1
    GENETIC_MODIFIERS["GENETIC MODIFIERS"]
    GENETIC_MODIFIERS -->|"associated with"| FAN1
    style FAN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
Huntingtonassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
HTTassociated_withgene0.60
PMS2associated_withgene0.60

Incoming (3)

SourceRelationTypeStr
MSH3associated_withgene0.60
GENETIC MODIFIERSassociated_withgene0.60
DNAactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found