gene

HTT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

699Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

HTT is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, inhibits. Associated with AMYOTROPHIC LATERAL SCLEROSIS, ATAXIA, Aging. Connected to 118 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HTT
Full Name	Huntingtin
Chromosome	4p16.3.
Protein Type	Cell Type
Function	is a large, multifunctional protein encoded by the HTT gene on chromosome 4p16.
Molecular Weight	350 kDa
Amino Acids	144 aa
Exons	67
Pathways	Autophagy, Dna Repair
UniProt ID	P42857
NCBI Gene ID	3064
Ensembl ID	ENSG00000197393
OMIM	143100
GeneCards	HTT
Human Protein Atlas	HTT
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	RAPAMYCIN, dimethyl fumarate, rapamycin
Interactions	P62, SQSTM1, TFEB, ULK1, MTOR, NFL
KG Connections	699 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: HTT — PDB 6EZ8 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HTT["HTT"] -->|"causes"| Dementia["Dementia"]
    HTT["HTT"] -->|"implicated in"| Huntington["Huntington"]
    HTT["HTT"] -->|"interacts"| Huntington_1["Huntington"]
    HTT["HTT"] -.->|"inhibits"| Huntington_2["Huntington"]
    HTT["HTT"] -->|"encodes"| huntingtin["huntingtin"]
    HTT["HTT"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Huntington_3["Huntington"] -->|"interacts"| HTT["HTT"]
    ACTB["ACTB"] -->|"associated"| HTT["HTT"]
    GABARAP["GABARAP"] -->|"associated"| HTT["HTT"]
    ULK1["ULK1"] -->|"associated"| HTT["HTT"]
    style HTT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (462)

Target	Relation	Type	Str
Huntington's Disease	causes	disease	0.95
amyloid-like fibrils	forms	phenotype	0.94
protein aggregation	promotes	process	0.90
Dementia	causes	disease	0.90
Huntington's disease	causes	disease	0.90
Calcium Homeostasis	regulates	process	0.85
ASK1	activates	protein	0.85
neurodegeneration	causes	disease	0.80
nuclear localization	promotes	process	0.80
Huntington's disease	associated_with	disease	0.80
Huntington's disease	treats	disease	0.80
neurons	expressed_in	cell_type	0.80
huntingtin	encodes	protein	0.70
striatum	expressed_in	brain_region	0.70
MAPT	interacts_with	protein	0.70
Huntington	implicated_in	entity	0.70
Huntington	interacts_with	entity	0.70
Huntington	inhibits	entity	0.70
stem cells	expressed_in	cell_type	0.70
astrocytes	expressed_in	cell_type	0.70
Huntington's disease	targets	disease	0.70
Spinal Muscular Atrophy	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Aging	treats	disease	0.65
Huntington	treats	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Huntington	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	causes	disease	0.65
Huntington	causes	disease	0.65
Ms	inhibits	disease	0.65
Huntington	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
ALS	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Als	causes	disease	0.65

Incoming (237)

Source	Relation	Type	Str
SDA-2026-04-02-gap-crispr-neurodegeneration-20260402	targets	analysis	0.90
HUNTINGTON	caused_by	disease	0.90
h-3a4f2027	targets_gene	hypothesis	0.90
h-10b5bf6f	targets_gene	hypothesis	0.90
Huntington	interacts_with	entity	0.70
DNA	regulates	gene	0.70
rapamycin	targets	drug	0.70
BDNF	phosphorylates	gene	0.65
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.65
DEPRESSION	causes	disease	0.65
ACTB	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
P62	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
MSH3	associated_with	gene	0.60
FAN1	associated_with	gene	0.60
DRP1	associated_with	gene	0.60
MFN1	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
SETX	associated_with	gene	0.60
ATG7	transports	gene	0.60
FKBP1A	inhibits	gene	0.60
LC3	inhibits	gene	0.60
FKBP5	inhibits	gene	0.60
ACTB	activates	entity	0.60
ALS4	activates	entity	0.60
ATG7	activates	entity	0.60
BECN1	activates	entity	0.60
DNMT1	activates	entity	0.60
GABARAP	activates	entity	0.60
HUNTINGTIN	causes	gene	0.60
TFEB	regulates	gene	0.60
HUNTINGTIN	therapeutic_target	gene	0.60
MTOR	inhibits	gene	0.60
CAG repeat expansion	associated_with	pathway	0.60
HUNTINGTIN	associated_with	gene	0.60
BDNF	inhibits	gene	0.60
HUNTINGTIN	inhibits	gene	0.60
RAB7	associated_with	gene	0.60
BDNF	activates	gene	0.60
REELIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HTT

Understanding Entity Pages

Summary

Wiki Pages (21)

Striatal Interneurons in Huntington's Disease

Novel Therapy Index

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

oxidative-stress-comparison

CNTN6 — Contactin 6

Huntington's Disease

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

rankings

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Copper Dyshomeostasis in Neurodegeneration

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

Splice-Modulating Therapies for Neurodegeneration

Protein Aggregation Comparison in Neurodegeneration

Non-Homologous End Joining in Neurodegeneration

Astrocytes

Nanobody Therapy for Neurodegenerative Diseases

RNA Therapeutics for Neurodegeneration Investment Landscape

Peroxisome Pathway in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Pathway Diagram

Outgoing (462)

Incoming (237)

Targeting Hypotheses (0)

Mentioning Analyses (2)

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Related Papers (0)