GALECTIN-3

Understanding Entity Pages

This page aggregates everything SciDEX knows about GALECTIN-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Galectin-3 (LGALS3) is a beta-galactosidase-binding lectin expressed in microglia, astrocytes, and neurons, playing critical roles in neuroinflammation, phagocytosis, and neurodegeneration in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

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graph TD
    GALECTIN_3(["GALECTIN-3"])
    TREM2(["TREM2"])
    Alzheimer_s_disease["Alzheimer's disease"]
    CLEC7A["CLEC7A"]
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER_S["ALZHEIMER'S"]
    microglia["microglia"]

    GALECTIN_3 -->|"interacts with"| TREM2
    GALECTIN_3 -->|"implicated in"| Alzheimer_s_disease
    GALECTIN_3 -->|"activates"| CLEC7A
    GALECTIN_3 -->|"activates"| ALZHEIMER
    GALECTIN_3 -->|"activates"| ALZHEIMER_S
    microglia -->|"activates"| GALECTIN_3

    style GALECTIN_3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style TREM2 fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
    style Alzheimer_s_disease fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style CLEC7A fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style ALZHEIMER fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style ALZHEIMER_S fill:#1a1a2e,stroke:#ffd54f,stroke-width:2px,color:#fff
    style microglia fill:#1a2a3a,stroke:#ffa726,stroke-width:2px,color:#fff