protein

GNAI1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAI1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gnai1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	GNAI1PROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the nervous system and plays critical roles in modulating neuronal signaling, synaptic transmission, and cellular responses to neurotransmitters
Subcellular Localization	- Cys palmitoylation: Additional membrane anchoring - Phosphorylation: S
GeneCards	GNAI1PROTEIN
Human Protein Atlas	GNAI1PROTEIN
N-terminal helix	Myristoylation site for membrane anchoring
Switch I region	Conformational changes between active/inactive states (residues 42-52)
Switch II region	Critical for GTP hydrolysis (residues 62-71)
Switch III region	Effector interaction interface (residues 87-97)
GTPase domain	Catalytic core for GTP hydrolysis (residues 35-190)
N-terminal glycine myristoylation	Required for membrane localization
Cys palmitoylation	Additional membrane anchoring
Phosphorylation	Serine/threonine phosphorylation regulates activity
Active state	Bound to GTP, able to interact with effectors
Associated Diseases	Als, Schizophrenia
Interactions	AKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, GNAI2
KG Connections	33 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

gnai1 Protein

protein · 995 words

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Pathway Diagram

graph TD
    GNAI1PROTEIN["GNAI1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GNAI1PROTEIN -->|"implicated_in"| neurodegeneration
    style GNAI1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GNAI1PROTEIN in their description or question text

No additional research found