protein

GRIN1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIN1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Glutamate Receptor Ionotropic NMDA Subunit 1 (GluN1), encoded by the GRIN1 gene, is the obligatory subunit of the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel critical for synaptic plasticity, learning, and memory.

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🔬 Protein Info

Gene Symbol	GRIN1PROTEIN
Chromosome	9q34.3
Function	Glutamate Receptor Ionotropic NMDA Subunit 1 (GluN1), encoded by the GRIN1 gene, is the obligatory subunit of the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel critical for sy...
Primary Expression	the central nervous system, particularly in the hippocampus, cerebral cortex, basal ganglia, and thalamus, where it plays fundamental roles in excitat
Molecular Weight	105 kDa
Amino Acids	938 aa
GeneCards	GRIN1PROTEIN
Human Protein Atlas	GRIN1PROTEIN
Associated Diseases	Huntington's disease, Memory Impairment
Known Drugs/Compounds	D-glutamate
Interactions	ADRA1A, ADRA1B, DRD1, DRD2, GRIA1, HCRTR1
KG Connections	58 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

grin1-protein

protein · 2041 words

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Pathway Diagram

graph TD
    GRIN1PROTEIN["GRIN1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRIN1PROTEIN -->|"implicated_in"| neurodegeneration
    style GRIN1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GRIN1PROTEIN in their description or question text

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