Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DRD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DRD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 103 entities in the SciDEX knowledge graph.
| Gene Symbol | DRD1 |
| Full Name | Dopamine Receptor D1 |
| Chromosome | 5q35.2 |
| Protein Type | Receptor |
| Function | The D1 receptor is a postsynaptic dopamine receptor that: |
| Primary Expression | Striatum, Cortex, Nucleus accumbens, Olfactory bulb |
| Pathways | MAPK |
| UniProt ID | P21709 |
| NCBI Gene ID | 1817 |
| Ensembl ID | ENSG00000184845 |
| GeneCards | DRD1 |
| Human Protein Atlas | DRD1 |
| Associated Diseases | ALS, Alzheimer, Autism, Bipolar, Cancer |
| Interactions | GRIA1, ADRA1A, HRH1, GRIN1, HCRTR1, MARCH7 |
| KG Connections | 284 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DRD1["DRD1"]
DRD1 -->|"activates"| Ms["Ms"]
DRD1 -->|"activates"| Als["Als"]
DRD1 -->|"regulates"| Inflammation["Inflammation"]
DRD1 -->|"target for"| Alzheimer["Alzheimer"]
DRD1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
DRD1 -->|"activates"| GRIA1["GRIA1"]
DRD1 -->|"activates"| ADRA1A["ADRA1A"]
DRD1 -->|"activates"| HRH1["HRH1"]
DRD2["DRD2"] -->|"activates"| DRD1
HRH3["HRH3"] -->|"activates"| DRD1
HCRTR2["HCRTR2"] -->|"activates"| DRD1
ADRA1B["ADRA1B"] -->|"activates"| DRD1
CLN3["CLN3"] -->|"target for"| DRD1
DMSO["DMSO"] -->|"target for"| DRD1
ERK["ERK"] -->|"activates"| DRD1
MICROGLIA["MICROGLIA"] -->|"regulates"| DRD1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| DRD1
ASTROCYTES["ASTROCYTES"] -->|"regulates"| DRD1| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| DRD2 | contributes_to | gene | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Huntington | associated_with | disease | 0.65 |
| Huntington | expressed_in | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Synucleinopathy | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Huntington | encodes | disease | 0.65 |
| NEURON | contributes_to | cell_type | 0.65 |
| TPH2 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| GRIA1 | activates | gene | 0.60 |
| ADRA1A | activates | gene | 0.60 |
| HRH1 | activates | gene | 0.60 |
| GRIN1 | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| SYNGR1 | associated_with | gene | 0.60 |
| GPNMB | therapeutic_target | gene | 0.60 |
| NLRP3 | therapeutic_target | gene | 0.60 |
| CX3CR1 | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| NEUROINFLAMMATION | treats | phenotype | 0.70 |
| HTR2A | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| SYNGR1 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| DRD2 | activates | gene | 0.60 |
| HRH3 | activates | gene | 0.60 |
| HCRTR2 | activates | gene | 0.60 |
| ADRA1B | activates | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| CLN3 | therapeutic_target | gene | 0.60 |
| CXCL10 | therapeutic_target | gene | 0.60 |
| C1QA | therapeutic_target | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| NLRP3 | therapeutic_target | gene | 0.60 |
| CX3CR1 | therapeutic_target | gene | 0.60 |
| GPNMB | therapeutic_target | gene | 0.60 |
| P2RY12 | therapeutic_target | gene | 0.60 |
| ESRRG | inhibits | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| DRD2 | inhibits | gene | 0.60 |
| TCF4 | expressed_in | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| CACNA1B | interacts_with | gene | 0.60 |
| CACNA1H | interacts_with | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| CNR1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||