gene

DRD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

284Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

DRD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 103 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDRD1
Full NameDopamine Receptor D1
Chromosome5q35.2
Protein TypeReceptor
FunctionThe D1 receptor is a postsynaptic dopamine receptor that:
Primary ExpressionStriatum, Cortex, Nucleus accumbens, Olfactory bulb
PathwaysMAPK
UniProt IDP21709
NCBI Gene ID1817
Ensembl IDENSG00000184845
GeneCardsDRD1
Human Protein AtlasDRD1
Associated DiseasesALS, Alzheimer, Autism, Bipolar, Cancer
InteractionsGRIA1, ADRA1A, HRH1, GRIN1, HCRTR1, MARCH7
KG Connections284 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: DRD1 — AlphaFold P21709 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

DRD1 Gene

gene · 1227 words

rgs9

gene · 3386 words

Mesolimbic Dopamine Pathway

mechanism · 3260 words

Dopamine Signaling Pathway

mechanism · 3237 words

medium-spiny-neurons-huntington-disease

cell_type · 3029 words

Serotonergic Dysfunction in Neurodegeneration

mechanism · 2965 words

Pathway Diagram

graph TD
    DRD1["DRD1"]
    DRD1 -->|"activates"| Ms["Ms"]
    DRD1 -->|"activates"| Als["Als"]
    DRD1 -->|"regulates"| Inflammation["Inflammation"]
    DRD1 -->|"target for"| Alzheimer["Alzheimer"]
    DRD1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    DRD1 -->|"activates"| GRIA1["GRIA1"]
    DRD1 -->|"activates"| ADRA1A["ADRA1A"]
    DRD1 -->|"activates"| HRH1["HRH1"]
    DRD2["DRD2"] -->|"activates"| DRD1
    HRH3["HRH3"] -->|"activates"| DRD1
    HCRTR2["HCRTR2"] -->|"activates"| DRD1
    ADRA1B["ADRA1B"] -->|"activates"| DRD1
    CLN3["CLN3"] -->|"target for"| DRD1
    DMSO["DMSO"] -->|"target for"| DRD1
    ERK["ERK"] -->|"activates"| DRD1
    MICROGLIA["MICROGLIA"] -->|"regulates"| DRD1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| DRD1
    ASTROCYTES["ASTROCYTES"] -->|"regulates"| DRD1

Outgoing (181)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
DRD2contributes_togene0.65
Schizophreniaassociated_withdisease0.65
Alsassociated_withdisease0.65
Depressionassociated_withdisease0.65

Incoming (103)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
NEUROINFLAMMATIONtreatsphenotype0.70
HTR2Aassociated_withgene0.60
DISC1associated_withgene0.60
FKBP5associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found