Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adra1b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADRA1B |
| Full Name | Alpha-1B Adrenergic Receptor |
| Aliases | α1B-AR |
| Chromosome | 5q23.3 |
| Protein Family | Adrenergic receptors (GPCR) |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Smooth muscle, brain, heart |
| Amino Acids | 515 aa |
| UniProt ID | P35368 |
| NCBI Gene ID | 147 |
| Ensembl ID | ENSG00000170175 |
| GeneCards | ADRA1B |
| Human Protein Atlas | ADRA1B |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ADRA1B["ADRA1B"]
ADRA1B -->|"activates"| Ms["Ms"]
ADRA1B -->|"activates"| Als["Als"]
ADRA1B -->|"activates"| Neuropathy["Neuropathy"]
ADRA1B -->|"activates"| Inflammation["Inflammation"]
ADRA1B -->|"activates"| DRD1["DRD1"]
ADRA1B -->|"activates"| GRIA1["GRIA1"]
ADRA1B -->|"activates"| ADRA1A["ADRA1A"]
ADRA1B -->|"activates"| HRH1["HRH1"]
DRD2["DRD2"] -->|"activates"| ADRA1B
HRH3["HRH3"] -->|"activates"| ADRA1B
HCRTR2["HCRTR2"] -->|"activates"| ADRA1B
INFLAMMATION["INFLAMMATION"] -->|"activates"| ADRA1B
AND["AND"] -->|"activates"| ADRA1B| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Neuropathy | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| DRD1 | activates | gene | 0.60 |
| GRIA1 | activates | gene | 0.60 |
| ADRA1A | activates | gene | 0.60 |
| HRH1 | activates | gene | 0.60 |
| GRIN1 | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Dna Methylation | activates | pathway | 0.60 |
| Hepatocyte | activates | cell_type | 0.60 |
| benchmark_ot_ad_answer_key:ADRA1B | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| DRD2 | activates | gene | 0.60 |
| HRH3 | activates | gene | 0.60 |
| HCRTR2 | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADRA1B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||