Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GUCY1B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GUCY1B1 encodes the beta subunit of soluble guanylate cyclase, which heterodimerizes with GUCY1A1 to form the NO-responsive enzyme that produces cGMP, critical for neurovascular function, synaptic plasticity, and implicated in Alzheimer's, Parkinson's, and cerebrovascular disease.
| Gene Symbol | GUCY1B1 |
| Full Name | Guanylate Cyclase 1 Soluble Subunit Beta 1 |
| Aliases | GUCY1B1, sGC-β1, GUCY1B, β1-sGC |
| Chromosome | 4q31.3 |
| Protein Family | Soluble guanylate cyclase subunits (GUCY1A1, GUCY1B1) |
| Protein Type | Enzyme - Guanylate cyclase |
| Function | The α₁β₁ sGC heterodimer performs multiple essential functions |
| Primary Expression | Both cytosolic and membrane-associated fractions, with the heterodimer distributed throughout the cytoplasm and in proximity to the plasma membrane |
| Subcellular Localization | Both cytosolic and membrane-associated fractions, with the heterodimer distributed throughout the cytoplasm and in proxi |
| Amino Acids | 619 aa |
| Pathways | Amyloid |
| UniProt ID | P21452 |
| NCBI Gene ID | 2983 |
| Ensembl ID | ENSG00000147862 |
| OMIM | 139397 |
| GeneCards | GUCY1B1 |
| Human Protein Atlas | GUCY1B1 |
| Associated Diseases | neurodegeneration |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GUCY1B1["<b>GUCY1B1</b>"]
Alzheimer["Alzheimer"]
GUCY1B1 -->|"regulates"| Alzheimer
NFKBIA["NFKBIA"]
GUCY1B1 -->|"regulates"| NFKBIA
GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
GUCY1B1 -->|"regulates"| GENETIC_RISK_LOCI
ALZHEIMER["ALZHEIMER"]
GUCY1B1 -->|"regulates"| ALZHEIMER
MEF2C["MEF2C"]
GUCY1B1 -->|"expressed in"| MEF2C
RBFOX2["RBFOX2"]
GUCY1B1 -->|"expressed in"| RBFOX2
RNA["RNA"]
GUCY1B1 -->|"regulates"| RNA
AND["AND"]
GUCY1B1 -->|"expressed in"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
GUCY1B1 -->|"regulates"| ALZHEIMER_S_DISEASE
AMYLOID["AMYLOID"]
GUCY1B1 -->|"regulates"| AMYLOID
TAU["TAU"]
GUCY1B1 -->|"regulates"| TAU
Amyloid["Amyloid"]
GUCY1B1 -->|"regulates"| Amyloid
NFKBIA["NFKBIA"]
NFKBIA -->|"regulates"| GUCY1B1
RBFOX2["RBFOX2"]
RBFOX2 -->|"expressed in"| GUCY1B1
TAU["TAU"]
TAU -->|"regulates"| GUCY1B1
MEF2C["MEF2C"]
MEF2C -->|"expressed in"| GUCY1B1
Cortex["Cortex"]
GUCY1B1 -->|"expressed in"| Cortex
Cerebellum["Cerebellum"]
GUCY1B1 -->|"expressed in"| Cerebellum
MEF2C["MEF2C"]
GUCY1B1 -->|"co discussed"| MEF2C
NFKBIA["NFKBIA"]
GUCY1B1 -->|"co discussed"| NFKBIA
RBFOX2["RBFOX2"]
GUCY1B1 -->|"co discussed"| RBFOX2
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"regulates"| GUCY1B1
AMYLOID["AMYLOID"]
AMYLOID -->|"regulates"| GUCY1B1
RNA["RNA"]
RNA -->|"regulates"| GUCY1B1
neurodegeneration["neurodegeneration"]
GUCY1B1 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | regulates | disease | 0.65 |
| NFKBIA | regulates | gene | 0.60 |
| MEF2C | expressed_in | gene | 0.60 |
| RBFOX2 | expressed_in | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| GENETIC RISK LOCI | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| Amyloid | regulates | pathway | 0.60 |
| hippocampus | expressed_in | brain_region | 0.60 |
| Cortex | expressed_in | brain_region | 0.55 |
| Cerebellum | expressed_in | brain_region | 0.55 |
| MEF2C | co_discussed | gene | 0.50 |
| NFKBIA | co_discussed | gene | 0.50 |
| RBFOX2 | co_discussed | protein | 0.50 |
| MEF2C | associated_with | gene | 0.50 |
| RBFOX2 | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||