Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RBFOX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RBFOX2 |
| Full Name | RNA Binding Fox-1 Homolog 2 (RBFOX2) |
| Chromosome | 22q12.3 |
| Protein Type | Gene |
| Function | It plays critical roles in |
| Molecular Weight | 44.5 kDa |
| Amino Acids | 90 aa |
| Pathways | Amyloid |
| UniProt ID | Q9BQY4 |
| NCBI Gene ID | 61643 |
| Ensembl ID | ENSG00000100320 |
| GeneCards | RBFOX2 |
| Human Protein Atlas | RBFOX2 |
| Associated Diseases | Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease, Cancer, Epilepsy, Autism Spectrum Disorder |
| Interactions | HNRNPM, CANCER |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RBFOX2["<b>RBFOX2</b>"]
Cancer{"Cancer"}
RBFOX2 -->|"interacts with"| Cancer
Tumor{"Tumor"}
RBFOX2 -->|"regulates"| Tumor
RAC1["RAC1"]
RBFOX2 -->|"expressed in"| RAC1
MYC["MYC"]
RBFOX2 -->|"regulates"| MYC
CANCER["CANCER"]
RBFOX2 -->|"interacts with"| CANCER
HNRNPM["HNRNPM"]
RBFOX2 -->|"interacts with"| HNRNPM
neurodegeneration["neurodegeneration"]
RBFOX2 -->|"implicated in"| neurodegeneration
style RBFOX2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | interacts_with | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| RAC1 | expressed_in | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| HNRNPM | interacts_with | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| MEF2C | expressed_in | gene | 0.60 |
| GUCY1B1 | expressed_in | gene | 0.60 |
| Nfkb | regulates | protein | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| CANCER | interacts_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| AMYLOID | regulates | gene | 0.60 |
| Amyloid | regulates | pathway | 0.60 |
| hippocampus | expressed_in | brain_region | 0.60 |
| Cortex | expressed_in | brain_region | 0.55 |
| Cerebellum | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NFKBIA | regulates | gene | 0.60 |
| GUCY1B1 | expressed_in | gene | 0.60 |
| MEF2C | expressed_in | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| GENETIC RISK LOCI | regulates | gene | 0.60 |
| GUCY1B1 | co_discussed | gene | 0.50 |
| MEF2C | co_discussed | gene | 0.50 |
| NFKBIA | co_discussed | gene | 0.50 |
| GUCY1B1 | associated_with | gene | 0.50 |
| MEF2C | associated_with | gene | 0.50 |
| ALZHEIMER | regulates | gene | 0.50 |
| AMYLOID | regulates | gene | 0.50 |
| RNA | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||