gene

MEF2C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEF2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

264Connections
1Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

MEF2C is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Cancer, Carcinoma, Lung Cancer. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMEF2C
Full NameMyocyte Enhancer Factor 2C
Chromosome5q14.1
Protein TypeTranscription Factor
Functionis a calcium-dependent transcription factor belonging to the MADS (MCM1, Agamous, Deficiens, serum response factor) box family of MEF2 proteins.
Molecular Weight~50 kDa
Exons15
PathwaysEffect on MEF2C
UniProt IDQ06413 (MEF2C)
NCBI Gene ID4208
Ensembl IDENSG00000081189
OMIM600662
GeneCardsMEF2C
Human Protein AtlasMEF2C
Protein ClassTranscription factor (MADS-box family)
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsNF2, NRF2, TFAM, HDAC4, TXN, MTOR
SciDEX HypothesesMEF2C-Dependent Synaptic Gene Regulation
KG Connections264 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: MEF2C — AlphaFold Q06413 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

mef2c

gene · 1929 words

gabaergic-dysfunction

mechanism · 4621 words

SETD1B

gene · 3299 words

ALS RNA Metabolism and Proteostasis Failure

mechanism · 3179 words

MEF2B (Myocyte Enhancer Factor 2B)

gene · 2829 words

setd1a

gene · 2794 words

Pathway Diagram

graph TD
    MEF2C["<b>MEF2C</b>"]
    Cancer{"Cancer"}
    MEF2C -->|"activates"| Cancer
    NF2["NF2"]
    MEF2C -->|"activates"| NF2
    FERROPTOSIS["FERROPTOSIS"]
    MEF2C -->|"activates"| FERROPTOSIS
    CANCER["CANCER"]
    MEF2C -->|"activates"| CANCER
    CDH1["CDH1"]
    MEF2C -->|"activates"| CDH1
    Ferroptosis(["Ferroptosis"])
    MEF2C -->|"activates"| Ferroptosis
    AND["AND"]
    MEF2C -->|"regulates"| AND
    Cortex["Cortex"]
    MEF2C -->|"expressed in"| Cortex
    Interneuron["Interneuron"]
    MEF2C -->|"expressed in"| Interneuron
    Neuron["Neuron"]
    MEF2C -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    MEF2C -->|"implicated in"| neurodegeneration
    style MEF2C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (161)

TargetRelationTypeStr
MIR133Aregulatesgene0.85
Canceractivatesdisease0.65
Tumorassociated_withdisease0.65
Melanomaassociated_withdisease0.65
Cancerassociated_withdisease0.65

Incoming (103)

SourceRelationTypeStr
CXCL12associated_withgene0.60
FOXM1causesgene0.60
IL6associated_withgene0.60
NR1H3causesgene0.60
RELBcausesgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
MEF2C-Dependent Synaptic Gene Regulation 0.578 neurodegeneration What molecular mechanisms mediate HDAC9'

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found