Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MEF2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MEF2C is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Cancer, Carcinoma, Lung Cancer. Connected to 24 entities in the SciDEX knowledge graph.
| Gene Symbol | MEF2C |
| Full Name | Myocyte Enhancer Factor 2C |
| Chromosome | 5q14.1 |
| Protein Type | Transcription Factor |
| Function | is a calcium-dependent transcription factor belonging to the MADS (MCM1, Agamous, Deficiens, serum response factor) box family of MEF2 proteins. |
| Molecular Weight | ~50 kDa |
| Exons | 15 |
| Pathways | Effect on MEF2C |
| UniProt ID | Q06413 (MEF2C) |
| NCBI Gene ID | 4208 |
| Ensembl ID | ENSG00000081189 |
| OMIM | 600662 |
| GeneCards | MEF2C |
| Human Protein Atlas | MEF2C |
| Protein Class | Transcription factor (MADS-box family) |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Cancer, Carcinoma |
| Known Drugs/Compounds | rapamycin |
| Interactions | NF2, NRF2, TFAM, HDAC4, TXN, MTOR |
| SciDEX Hypotheses | MEF2C-Dependent Synaptic Gene Regulation |
| KG Connections | 264 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MEF2C["<b>MEF2C</b>"]
Cancer{"Cancer"}
MEF2C -->|"activates"| Cancer
NF2["NF2"]
MEF2C -->|"activates"| NF2
FERROPTOSIS["FERROPTOSIS"]
MEF2C -->|"activates"| FERROPTOSIS
CANCER["CANCER"]
MEF2C -->|"activates"| CANCER
CDH1["CDH1"]
MEF2C -->|"activates"| CDH1
Ferroptosis(["Ferroptosis"])
MEF2C -->|"activates"| Ferroptosis
AND["AND"]
MEF2C -->|"regulates"| AND
Cortex["Cortex"]
MEF2C -->|"expressed in"| Cortex
Interneuron["Interneuron"]
MEF2C -->|"expressed in"| Interneuron
Neuron["Neuron"]
MEF2C -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
MEF2C -->|"implicated in"| neurodegeneration
style MEF2C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MIR133A | regulates | gene | 0.85 |
| Cancer | activates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Melanoma | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Lung Cancer | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Pain | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Autism | activates | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Autism | encodes | disease | 0.65 |
| NF2 | activates | gene | 0.60 |
| PTK2B | associated_with | gene | 0.60 |
| FERMT2 | associated_with | gene | 0.60 |
| RIN3 | associated_with | gene | 0.60 |
| ZCWPW1 | associated_with | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| microglial phenotype | modulates | phenotype | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| GUCY1B1 | expressed_in | gene | 0.60 |
| EPHA5 | regulates | gene | 0.60 |
| NLGN1 | regulates | gene | 0.60 |
| DCC | regulates | gene | 0.60 |
| HDAC4 | activates | gene | 0.60 |
| TXN | activates | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| MAPT | activates | gene | 0.60 |
| ADORA1 | activates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| RBFOX2 | expressed_in | gene | 0.60 |
| NRGN | inhibits | gene | 0.60 |
| GAIN | expressed_in | gene | 0.60 |
| MECP2 | expressed_in | gene | 0.60 |
| Dendritic Spine | regulates | pathway | 0.60 |
| SLC2A1 | activates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CXCL12 | associated_with | gene | 0.60 |
| FOXM1 | causes | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| NR1H3 | causes | gene | 0.60 |
| RELB | causes | gene | 0.60 |
| PLD3 | associated_with | gene | 0.60 |
| ABCA7 | associated_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| PICALM | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| CASS4 | associated_with | gene | 0.60 |
| CD33 | associated_with | gene | 0.60 |
| NME8 | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| CD2AP | associated_with | gene | 0.60 |
| INPP5D | associated_with | gene | 0.60 |
| EPHA1 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CELF1 | associated_with | gene | 0.60 |
| TXN | activates | gene | 0.60 |
| SLC2A1 | activates | gene | 0.60 |
| Type I interferon | regulates | protein | 0.60 |
| brain aging | regulates | process | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| ADORA1 | activates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| MAPT | activates | gene | 0.60 |
| NFKBIA | regulates | gene | 0.60 |
| RBFOX2 | expressed_in | gene | 0.60 |
| NGN1 | regulates | gene | 0.60 |
| NGN2 | regulates | gene | 0.60 |
| NRGN | inhibits | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| GUCY1B1 | expressed_in | gene | 0.60 |
| DCC | regulates | gene | 0.60 |
| CREB1 | expressed_in | gene | 0.60 |
| HDAC4 | activates | gene | 0.60 |
| NESTIN | expressed_in | gene | 0.60 |
| NLGN1 | regulates | gene | 0.60 |
| EPHA5 | regulates | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| MEF2 | activates | gene | 0.60 |
| ABCA7 | interacts_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| CASS4 | interacts_with | gene | 0.60 |
| CD2AP | interacts_with | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| CELF1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| MEF2C-Dependent Synaptic Gene Regulation | 0.578 | neurodegeneration | What molecular mechanisms mediate HDAC9' |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||