protein

HCN1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCN1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

HCN1 (Hyperpolarization-activated Cyclic Nucleotide-gated channel 1) is a voltage-gated ion channel that generates the hyperpolarization-activated current (I_h), also known as the "pacemaker current.

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🔬 Protein Info

Gene Symbol	HCN1PROTEIN
Protein Type	Channel
Target Class	Ion Channel
Function	is a voltage-gated ion channel that generates the hyperpolarization-activated current (I_h), also known as the "pacemaker current.
Mechanism of Action	HCN1 encodes a hyperpolarization-activated cyclic nucleotide-gated channel critical for neuronal pacemaking and synaptic integration, with dysregulation linked to hyperexcitability disorders and potential neurodegeneration mechanisms. Specifically, HCN1 channel dysfunction can alter neuronal excitability, synaptic plasticity, and potentially contribute to neuronal death or dysfunction in conditions like epilepsy and neurodegenerative diseases.
Subcellular Localization	Isoform-specific trafficking to different neuronal compartments
Druggability	Medium (0.51)
Clinical Stage	Approved
Molecular Weight	100 kDa
Amino Acids	910 aa
GeneCards	HCN1PROTEIN
Human Protein Atlas	HCN1PROTEIN
S5-S6 (Amino acids 300-450)	The pore domain forms the ion conduction pathway. The P-loop between S5 and S6 contains the selectivity filter that determines ion selectivity.
Biophysical properties	Different isoforms have distinct activation and deactivation kinetics
Modulation	Heteromeric channels have intermediate pharmacological properties
Associated Diseases	Absence Seizures, AD, ALI, Als, Alzheimer's disease
Known Drugs/Compounds	ketamine, propofol, Propofol, Zd7288
Interactions	AND, App, BDNF, C1Q, EPILEPSY, Fus
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HCN1-Mediated Resonance Frequency Stabilization Th HCN1-Selective Blockade Normalizes Thalamic Reboun Ion Channel Stabilization (HCN1/Kv7)
KG Connections	332 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

hcn1-protein

protein · 2123 words

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Pathway Diagram

graph TD
    HCN1PROTEIN["HCN1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HCN1PROTEIN -->|"implicated_in"| neurodegeneration
    style HCN1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

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