gene

HLADRB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HLADRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

HLA-DRB1 — MHC Class II DR Beta 1

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🧬 Gene Info

Gene Symbol	HLA
Full Name	DRB1 — Major Histocompatibility Complex Class II DR Beta 1
Primary Expression	Ca1, Cortex
Pathways	Jak-Stat, Apoptosis, Necroptosis, Epigenetic, Immune Response
GeneCards	HLA
Human Protein Atlas	HLA
Antigen Presentation	HLA-DRB1 presents peptide antigens (typically 13-25 amino acids) to CD4+ T helper cells, initiating adaptive immune responses.
Immune Regulation	Different HLA-DRB1 alleles confer susceptibility or resistance to various autoimmune diseases.
T Cell Development	Essential for positive and negative selection of CD4+ T cells in the thymus.
Tissue Immune Surveillance	MHC class II expression can be induced on glial cells in the brain during inflammation.
Microglial Activation	HLA molecules are involved in antigen presentation in the brain, potentially modulating microglial responses to Aβ and tau pathology.<sup>[4]</sup>
Autoimmunity	Some HLA-DRB1 variants may predispose to autoimmune responses that cross-react with brain antigens.
Chronic Inflammation	Sustained HLA-DRB1-mediated immune responses may contribute to chronic neuroinflammation.
Immune Tissues	High expression in spleen, lymph nodes, thymus, peripheral blood leukocytes
Brain	Low basal expression; upregulated on microglia and astrocytes in AD and MS brains
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cardiovascular
Interactions	ABCA7, AGER, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE
KG Connections	291 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: HLADRB1 — AlphaFold P01911 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HLA-DRB1 — MHC Class II DR Beta 1

gene · 787 words

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Pathway Diagram

graph TD
    HLADRB1["HLADRB1"]
    neurodegeneration["neurodegeneration"]
    HLADRB1 -->|"implicated_in"| neurodegeneration
    style HLADRB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning HLADRB1 in their description or question text

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