Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIGH GLUCOSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HIGH GLUCOSE |
Knowledge base pages for this entity
graph TD
HIGH_GLUCOSE[HIGH GLUCOSE]
HIGH_GLUCOSE -->|causes| Diabetic_Kidney_Disease[Diabetic Kidney Disease]
HIGH_GLUCOSE -->|inhibits| lipophagy[lipophagy]
HIGH_GLUCOSE -->|causes| Amyloidogenesis[Amyloidogenesis]
HIGH_GLUCOSE -->|causes| HK_2_Cell_Apoptosis[HK-2 Cell Apoptosis]
HIGH_GLUCOSE -->|upregulates| IL6[IL6]
HIGH_GLUCOSE -->|upregulates| IL1B[IL1B]
HIGH_GLUCOSE -->|upregulates| TNFA[TNFA]
HIGH_GLUCOSE -->|causes| kidney_injury[kidney injury]
HIGH_GLUCOSE -->|upregulates| LDH[LDH]| Target | Relation | Type | Str |
|---|---|---|---|
| Diabetic Kidney Disease | causes | disease | 0.95 |
| Diabetic Kidney Disease | causes | disease | 0.95 |
| lipophagy | inhibits | pathway | 0.90 |
| Amyloidogenesis | causes | process | 0.90 |
| HK-2 Cell Apoptosis | causes | process | 0.90 |
| IL6 | upregulates | gene | 0.90 |
| IL1B | upregulates | gene | 0.90 |
| TNFA | upregulates | gene | 0.90 |
| kidney injury | causes | phenotype | 0.90 |
| Sirt6-Mir-216/217 Axis | associated_with | mechanism | 0.85 |
| LDH | upregulates | gene | 0.85 |
| KIM1 | upregulates | gene | 0.85 |
| TGFB1 | upregulates | gene | 0.85 |
| COL4 | upregulates | gene | 0.85 |
| apoptosis | promotes | process | 0.85 |
| SIRT6 | downregulates | gene | 0.80 |
| p38-MAPK | activates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity