Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LIPOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LIPOPHAGY is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 229 entities in the SciDEX knowledge graph.
| Name | LIPOPHAGY |
| Key Genes/Proteins | AUTOPHAGY, LC3B, MTOR, INFLAMMATION, AMPK |
| Related Diseases | Als, Inflammation, Atherosclerosis, Fatty Liver |
| Related Pathways | Autophagy, Lipid Metabolism, Mtor |
Knowledge base pages for this entity
graph TD
LIPOPHAGY["LIPOPHAGY"]
LIPOPHAGY -->|"regulates"| lipid_homeostasis["lipid homeostasis"]
LIPOPHAGY -.protects against.-> insulin_resistance["insulin resistance"]
LIPOPHAGY -.protects against.-> neurodegeneration["neurodegeneration"]
LIPOPHAGY -->|"treats"| lipid_storage_myopathy["lipid storage myopathy"]
LIPOPHAGY -.protects against.-> clear_cell_renal_carcinoma["clear cell renal carcinoma"]
LIPOPHAGY -.protects against.-> cancer_metastasis["cancer metastasis"]
LIPOPHAGY -->|"inhibits"| intracellular_lipid_burden["intracellular lipid burden"]
LIPOPHAGY -->|"activates"| Hepatitis["Hepatitis"]
LIPOPHAGY -->|"activates"| Ms["Ms"]
LIPOPHAGY -->|"activates"| Inflammation["Inflammation"]
sulforaphane["sulforaphane"] -->|"activates"| LIPOPHAGY
high_glucose["high glucose"] -->|"inhibits"| LIPOPHAGY
TREM1["TREM1"] -->|"inhibits"| LIPOPHAGY
RAB7A["RAB7A"] -->|"regulates"| LIPOPHAGY
STING1["STING1"] -->|"inhibits"| LIPOPHAGY
OPTN["OPTN"] -->|"regulates"| LIPOPHAGY
TFEB["TFEB"] -->|"regulates"| LIPOPHAGY
NBR1["NBR1"] -->|"regulates"| LIPOPHAGY
autophagy["autophagy"] -->|"regulates"| LIPOPHAGY
MTORC1["MTORC1"] -->|"inhibits"| LIPOPHAGY| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | pathway | 1.00 |
| Als | activates | disease | 0.95 |
| Lipid Metabolism | activates | pathway | 0.90 |
| Mtor | activates | pathway | 0.90 |
| AUTOPHAGY | activates | gene | 0.90 |
| Autophagy | activates | pathway | 0.90 |
| Autophagy | associated_with | pathway | 0.90 |
| Lipid Metabolism | regulates | pathway | 0.90 |
| Inflammation | therapeutic_target | disease | 0.85 |
| Atherosclerosis | associated_with | disease | 0.85 |
| Fatty Liver | activates | disease | 0.85 |
| MTOR | activates | gene | 0.80 |
| Hepatitis | activates | disease | 0.75 |
| Diabetes | activates | disease | 0.75 |
| Als | associated_with | disease | 0.75 |
| Cancer | associated_with | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| Obesity | associated_with | disease | 0.75 |
| Nafld | therapeutic_target | disease | 0.75 |
| Fatty Liver | regulates | disease | 0.75 |
| Neurodegeneration | associated_with | disease | 0.75 |
| Fatty Liver | associated_with | disease | 0.75 |
| AUTOPHAGY | associated_with | gene | 0.70 |
| AUTOPHAGY | regulates | gene | 0.70 |
| Ferroptosis | activates | pathway | 0.70 |
| Cholesterol | activates | pathway | 0.70 |
| Lipid Metabolism | associated_with | pathway | 0.70 |
| ULK1 | activates | gene | 0.70 |
| Ms | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Hepatitis | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Carcinoma | regulates | disease | 0.65 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Metabolic Syndrome | causes | disease | 0.65 |
| Fatty Liver | causes | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| Atherosclerosis | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LC3B | associated_with | gene | 0.80 |
| INFLAMMATION | therapeutic_target | gene | 0.80 |
| AMPK | activates | gene | 0.80 |
| AUTOPHAGY | regulates | gene | 0.80 |
| AUTOPHAGY | associated_with | gene | 0.80 |
| RAB7A | regulates | gene | 0.72 |
| TFEB | activates | gene | 0.70 |
| FERROPTOSIS | activates | gene | 0.70 |
| CANCER | associated_with | gene | 0.70 |
| ATG5 | activates | gene | 0.70 |
| CANCER | activates | gene | 0.70 |
| LYSOSOME | regulates | gene | 0.70 |
| FAS | inhibits | gene | 0.70 |
| PLIN2 | associated_with | gene | 0.70 |
| NEURODEGENERATION | associated_with | gene | 0.70 |
| LC3 | activates | gene | 0.70 |
| EXERCISE | activates | gene | 0.70 |
| STING1 | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| TREM1 | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| FERROPTOSIS | regulates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| RAB7A | inhibits | gene | 0.60 |
| TLR8 | inhibits | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| PIK3CA | associated_with | gene | 0.60 |
| CDK6 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| TGFBR1 | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| NCOA4 | regulates | gene | 0.60 |
| ATG4B | activates | gene | 0.60 |
| ATG3 | activates | gene | 0.60 |
| ATG13 | activates | gene | 0.60 |
| ATG7 | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AUTOPHAGY | implicated_in | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| ATG16L1 | inhibits | gene | 0.60 |
| DIABETES MELLITUS | therapeutic_target | gene | 0.60 |
| MTORC1 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||