protein

IGF1RPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1RPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Insulin Like Growth Factor 1 Receptor Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	IGF1RPROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain and plays essential roles in neuronal development, synaptic plasticity, and neuroprotection
Subcellular Localization	</th><td>Cell Membrane</td></tr>
Molecular Weight	180 kDa
Amino Acids	706 aa
GeneCards	IGF1RPROTEIN
Human Protein Atlas	IGF1RPROTEIN
Ligand-binding domain	Contains multiple repeats of leucine-rich motifs
Cysteine-rich regions	Provide structural stability
Fibronectin type III domains	Facilitate receptor dimerization
Single transmembrane helix	Anchors receptor in membrane
Tyrosine kinase domain	Catalytic core (residues 1085-1281)
C-terminal tail	Contains regulatory tyrosine residues
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, Diabetes
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta
KG Connections	335 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Insulin-Like Growth Factor 1 Receptor Protein

protein · 836 words

→

Pathway Diagram

graph TD
    IGF1RPROTEIN["IGF1RPROTEIN"]
    neurodegeneration["neurodegeneration"]
    IGF1RPROTEIN -->|"implicated_in"| neurodegeneration
    style IGF1RPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF1RPROTEIN in their description or question text

No additional research found