| Gene Symbol | IGF1RPROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain and plays essential roles in neuronal development, synaptic plasticity, and neuroprotection |
| Subcellular Localization | </th><td>Cell Membrane</td></tr> |
| Molecular Weight | 180 kDa |
| Amino Acids | 706 aa |
| GeneCards | IGF1RPROTEIN |
| Human Protein Atlas | IGF1RPROTEIN |
| Ligand-binding domain | Contains multiple repeats of leucine-rich motifs |
| Cysteine-rich regions | Provide structural stability |
| Fibronectin type III domains | Facilitate receptor dimerization |
| Single transmembrane helix | Anchors receptor in membrane |
| Tyrosine kinase domain | Catalytic core (residues 1085-1281) |
| C-terminal tail | Contains regulatory tyrosine residues |
| Associated Diseases | AD, ALS, Alzheimer, Alzheimer's disease, DIABETES |
| Interactions | TNF, IGF1, BDNF, PDGFRB, PI3K, RELA |
| KG Connections | 340 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |