| Gene Symbol | IGF1RPROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain and plays essential roles in neuronal development, synaptic plasticity, and neuroprotection |
| Subcellular Localization | </th><td>Cell Membrane</td></tr> |
| Molecular Weight | 180 kDa |
| Amino Acids | 706 aa |
| GeneCards | IGF1RPROTEIN |
| Human Protein Atlas | IGF1RPROTEIN |
| Ligand-binding domain | Contains multiple repeats of leucine-rich motifs |
| Cysteine-rich regions | Provide structural stability |
| Fibronectin type III domains | Facilitate receptor dimerization |
| Single transmembrane helix | Anchors receptor in membrane |
| Tyrosine kinase domain | Catalytic core (residues 1085-1281) |
| C-terminal tail | Contains regulatory tyrosine residues |
| Associated Diseases | AD, Als, Alzheimer, Alzheimer's disease, Diabetes |
| Interactions | AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta |
| KG Connections | 335 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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