Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IMPDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | IMPDH1 |
| Full Name | IMPDH1 - Inosine Monophosphate Dehydrogenase 1 |
| Aliases | Page for IMPDH1 Gene, Inosine Monophosphate Dehydrogenase 1 |
| Chromosome | 7q31.3 |
| Protein Type | Gene |
| Primary Expression | neurons throughout the CNS, particularly in: - Cerebral cortex - [Hippocampus](/brain-regions/hippoc |
| Molecular Weight | 56 kDa |
| Pathways | Glycolysis |
| UniProt ID | P20839 |
| NCBI Gene ID | 3616 |
| GeneCards | IMPDH1 |
| Human Protein Atlas | IMPDH1 |
| Official Name | Inosine-5'-monophosphate dehydrogenase 1 |
| Uniprot ID | P20839 |
| Quaternary structure | Tetrameric enzyme (four identical subunits) |
| Associated Diseases | neurodegeneration |
| Interactions | MYC, TP53 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["IMPDH1"]
N1["Autoimmune"]
N0 -->|"therapeutic target"| N1
N2["Neuroinflammation"]
N0 -->|"therapeutic target"| N2
N3["Inflammation"]
N0 -->|"therapeutic target"| N3
N4["Leukemia"]
N0 -->|"inhibits"| N4
N5["Oxidative Phosphorylation"]
N0 -->|"inhibits"| N5
N6["Glycolysis"]
N0 -->|"activates"| N6
N7["Stem Cell"]
N0 -->|"inhibits"| N7
N8["TP53"]
N8 -->|"activates"| N0
N9["MYC"]
N9 -->|"activates"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 disease
class N5 pathway
class N6 pathway
class N7 pathway
class N8 gene
class N9 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Autoimmune | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Leukemia | inhibits | disease | 0.65 |
| Oxidative Phosphorylation | inhibits | pathway | 0.60 |
| Glycolysis | activates | pathway | 0.60 |
| Stem Cell | inhibits | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IMPDH1 in their description or question text
No additional research found