disease

Leukemia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Leukemia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

716Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Leukemia is a disease characterized by neurodegeneration research. Key relationships include: therapeutic target, activates, associated with. Associated with Aging, Als, Alzheimer. Connected to 536 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	AKT, MTOR, PI3K, SETDB1, CANCER, JAK, COMPLEMENT, TP53
KG Connections	649 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Leukemia["Leukemia"] -->|"activates"| Epigenetic["Epigenetic"]
    Leukemia["Leukemia"] -->|"activates"| Wnt["Wnt"]
    Leukemia["Leukemia"] -.->|"inhibits"| Epigenetic_1["Epigenetic"]
    Leukemia["Leukemia"] -->|"activates"| Hedgehog["Hedgehog"]
    Leukemia["Leukemia"] -->|"activates"| Tgf__["Tgf-Beta"]
    Leukemia["Leukemia"] -->|"associated"| Complement["Complement"]
    JUN["JUN"] -->|"activates"| Leukemia["Leukemia"]
    XPO1["XPO1"] -->|"expressed in"| Leukemia["Leukemia"]
    NPM1["NPM1"] -->|"biomarker for"| Leukemia["Leukemia"]
    MCL1["MCL1"] -.->|"inhibits"| Leukemia["Leukemia"]
    style Leukemia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (210)

Target	Relation	Type	Str
Apoptosis	activates	pathway	1.00
Mtor	therapeutic_target	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Als	therapeutic_target	disease	1.00
Stem Cell	therapeutic_target	pathway	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Apoptosis	inhibits	pathway	0.90
Pi3K/Akt	therapeutic_target	pathway	0.90
Nf-Κb	therapeutic_target	pathway	0.90
Cancer	therapeutic_target	disease	0.85
Cancer	activates	disease	0.85
Cell Cycle	therapeutic_target	pathway	0.80
Notch	therapeutic_target	pathway	0.80
Car-T	therapeutic_target	pathway	0.80
Nf-Κb	activates	pathway	0.80
Metastasis	therapeutic_target	pathway	0.80
Cancer	associated_with	disease	0.75
Als	expressed_in	disease	0.75
Lymphoma	inhibits	disease	0.75
Mtor	regulates	pathway	0.70
Angiogenesis	therapeutic_target	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Jak-Stat	therapeutic_target	pathway	0.70
Angiogenesis	inhibits	pathway	0.70
Oxidative Phosphorylation	therapeutic_target	pathway	0.70
Pi3K/Akt	inhibits	pathway	0.70
Differentiation	therapeutic_target	pathway	0.70
Drug Resistance	inhibits	pathway	0.70
Chemoresistance	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Invasion	therapeutic_target	pathway	0.70
Multidrug Resistance	therapeutic_target	pathway	0.70
Tumor Microenvironment	therapeutic_target	pathway	0.70
Differentiation	activates	pathway	0.70
Stem Cell	activates	pathway	0.70
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Myelodysplastic Syndrome	associated_with	disease	0.65
Breast Cancer	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Lung Cancer	activates	disease	0.65
Als	treats	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Colorectal Cancer	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Lung Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Epigenetic	activates	pathway	0.60

Incoming (506)

Source	Relation	Type	Str
BCL2	inhibits	gene	1.00
BCL-2	therapeutic_target	gene	1.00
MTOR	therapeutic_target	gene	1.00
PI3K	therapeutic_target	gene	1.00
BCL2	therapeutic_target	gene	1.00
AKT	therapeutic_target	gene	1.00
GENES	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
CANCER	associated_with	gene	1.00
CANCER	inhibits	gene	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	activates	disease	1.00
TP53	therapeutic_target	gene	0.95
APOPTOSIS	inhibits	gene	0.95
AKT	inhibits	gene	0.95
NF-ΚB	therapeutic_target	gene	0.95
CHIP	risk_factor_for	disease	0.90
GENES	activates	gene	0.85
STAT3	activates	gene	0.85
OVERVIEW	therapeutic_target	gene	0.85
PI3K	inhibits	gene	0.85
MYC	activates	gene	0.85
CANCER	expressed_in	gene	0.85
PI3K	regulates	gene	0.85
CAR T Cell Therapy	treats	cell_type	0.85
Cancer	inhibits	disease	0.85
Tumor	inhibits	disease	0.85
NF-ΚB	activates	gene	0.85
NUCLEAR JAK	contributes_to	protein	0.85
DNMT3A	associated_with	gene	0.80
LRP1	targets	protein	0.80
EGFR	activates	gene	0.75
DNA	activates	gene	0.75
ABL1	therapeutic_target	gene	0.75
MTOR	regulates	gene	0.75
BAX	therapeutic_target	gene	0.75
MYC	therapeutic_target	gene	0.75
GAIN	therapeutic_target	gene	0.75
LIFR	activates	gene	0.75
LIF	activates	gene	0.75
CD33	therapeutic_target	gene	0.75
BCL2	activates	gene	0.75
APOPTOSIS	regulates	gene	0.75
APOPTOSIS	expressed_in	gene	0.75
CANCER	regulates	gene	0.75
AUTOPHAGY	therapeutic_target	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Leukemia

Understanding Entity Pages

Summary

Wiki Pages (20)

NPM1 Gene

Astrocyte Reactivity Mechanism

nf1-protein

PEN2 Gene

CNTF Signaling Pathway in Neurodegeneration

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

CNTFR Gene

Gamma-Secretase Complex (γ-Secretase)

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Litronesib (LY317615/Enzastaurin)

Apoptosis Pathway in Neurodegeneration

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

ataxia-telangiectasia

Cerebellar Degeneration Pathway

RAD21 — Cohesin Complex Component in Neurodegeneration

Kyowa Kirin Co., Ltd.

IL3 (Interleukin 3)