concept

ITGA2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITGA2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

23Outgoing

4Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ITGA2B
Key Genes/Proteins	IL-6, IL6, ILK
Related Diseases	Myocardial Injury, High-Altitude Myocardial Injury, Aging, ALS, Als
Related Pathways	ILK/NF-κB Signaling, Glycolysis, ILK/NF-κB, GLYCOLYSIS, Oxidative Phosphorylation

Wiki Pages (2)

Knowledge base pages for this entity

IL6ST - Interleukin 6 Signal Transducer (gp130)

gene · 1853 words

→

ITGB3 Protein (Integrin Beta-3)

protein · 590 words

→

Pathway Diagram

graph TD
    ITGA2B["ITGA2B"]
    ITGA2B -->|"upregulates"| IL_6["IL-6"]
    ITGA2B -->|"activates"| ILK_NF__B_Signaling["ILK/NF-kappaB Signaling"]
    ITGA2B -->|"upregulates"| Glycolysis["Glycolysis"]
    ITGA2B -->|"activates"| ILK_NF__B["ILK/NF-kappaB"]
    ITGA2B -->|"causes"| Myocardial_Injury["Myocardial Injury"]
    ITGA2B -.biomarker for.-> High_Altitude_Myocardial_Injur["High-Altitude Myocardial Injury"]
    ITGA2B -->|"regulates"| IL6["IL6"]
    ITGA2B -->|"expressed in"| Aging["Aging"]
    IL_6 -->|"activates"| ITGA2B
    AND["AND"] -->|"activates"| ITGA2B
    NF__B["NF-KappaB"] -->|"activates"| ITGA2B
    HYPOXIA["HYPOXIA"] -->|"activates"| ITGA2B

Outgoing (23)

Target	Relation	Type	Str
IL-6	upregulates	protein	0.95
ILK/NF-κB Signaling	activates	pathway	0.90
Glycolysis	upregulates	pathway	0.90
ILK/NF-κB	activates	pathway	0.90
Myocardial Injury	causes	disease	0.85
High-Altitude Myocardial Injury	biomarker_for	disease	0.80
IL6	regulates	protein	0.72
Aging	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
ILK	activates	protein	0.64
GLYCOLYSIS	activates	pathway	0.64
MYOCARDIAL_INJURY	causes	disease	0.64
Oxidative Phosphorylation	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
NF-ΚB	activates	gene	0.60
AND	activates	gene	0.60
IL-6	activates	gene	0.60
Interleukin	activates	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
OXIDATIVE_PHOSPHORYLATION	inhibits	pathway	0.56

Incoming (4)

Source	Relation	Type	Str
IL-6	activates	gene	0.60
AND	activates	gene	0.60
NF-ΚB	activates	gene	0.60
HYPOXIA	activates	phenotype	0.56

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found