NF-kB signaling

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-kB signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"crosstalk with"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K_AKT_mTOR_signaling fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NF_kB_signaling["NF-kB signaling"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NEMO["NEMO"] -->|"activates"| NF_kB_signaling["NF-kB signaling"]
    style NEMO fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| NF_kB_signaling["NF-kB signaling"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TLR4["TLR4"] -->|"participates in"| NF_kB_signaling["NF-kB signaling"]
    style TLR4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| NF_kB_signaling["NF-kB signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| NF_kB_signaling["NF-kB signaling"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style NF_kB_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold