concept

INTERLEUKIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERLEUKIN

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interleukin-6 (IL-6)

entity · 957 words

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Pathway Diagram

graph TD
    INTERLEUKIN["INTERLEUKIN"]
    style INTERLEUKIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERLEUKIN -->|"regulates"| Fibrosis["Fibrosis"]
    INTERLEUKIN -->|"target for"| Als["Als"]
    INTERLEUKIN -->|"interacts"| Cancer["Cancer"]
    INTERLEUKIN -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    INTERLEUKIN -->|"target for"| Neuroinflammation["Neuroinflammation"]
    REL([REL]) -->|"regulates"| INTERLEUKIN
    IL_10([IL-10]) -->|"activates"| INTERLEUKIN
    CERS2([CERS2]) -->|"regulates"| INTERLEUKIN
    IGF1R([IGF1R]) -->|"regulates"| INTERLEUKIN
    DAG1([DAG1]) -->|"regulates"| INTERLEUKIN
    RNA([RNA]) -->|"regulates"| INTERLEUKIN
    ROS([ROS]) -->|"regulates"| INTERLEUKIN
    HSPG2([HSPG2]) -->|"regulates"| INTERLEUKIN
    RIPK1([RIPK1]) -->|"interacts"| INTERLEUKIN
    PPARG([PPARG]) -->|"interacts"| INTERLEUKIN

Outgoing (189)

Target	Relation	Type	Str
Aging	protects_against	disease	0.60
Senescence	protects_against	disease	0.60
Cancer	regulates	disease	0.60
Encephalitis	inhibits	disease	0.60
Meningitis	inhibits	disease	0.60
Dementia	expressed_in	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Stroke	expressed_in	disease	0.60
Diabetes	inhibits	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Multiple Sclerosis	interacts_with	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Encephalitis	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Lymphoma	activates	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Migraine	associated_with	disease	0.60
Ferroptosis	associated_with	disease	0.60
Obesity	therapeutic_target	disease	0.60
Als	regulates	disease	0.60
Stroke	regulates	disease	0.60
Alzheimer	inhibits	disease	0.60
Epilepsy	inhibits	disease	0.60
Alzheimer	activates	disease	0.60
Pyroptosis	causes	disease	0.60
Stroke	therapeutic_target	disease	0.60
Diabetes	activates	disease	0.60
Als	associated_with	disease	0.60
Leukemia	therapeutic_target	disease	0.60
Cancer	associated_with	disease	0.60
Stroke	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Atherosclerosis	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Cancer	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Als	activates	disease	0.60
Als	expressed_in	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Pyroptosis	biomarker_for	disease	0.60
Necroptosis	biomarker_for	disease	0.60
Ferroptosis	biomarker_for	disease	0.60
Parkinson	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60

Incoming (474)

Source	Relation	Type	Str
STROKE	activates	gene	0.60
AMPK	activates	gene	0.60
CD68	activates	gene	0.60
CX3CR1	activates	gene	0.60
CD36	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PPAR	activates	gene	0.60
TNF	activates	gene	0.60
IL-1	activates	gene	0.60
CD163	activates	gene	0.60
SIRT1	activates	gene	0.60
HEDGEHOG	activates	gene	0.60
HIPPO	activates	gene	0.60
EGFR	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
ITGA2B	activates	gene	0.60
IL-6	activates	gene	0.60
MYELIN	expressed_in	gene	0.60
VEGF	expressed_in	gene	0.60
AKT	activates	gene	0.60
P38	activates	gene	0.60
PRDX1	activates	gene	0.60
ERK1/2	activates	gene	0.60
CYTOKINES	regulates	gene	0.60
IL-6	transports	gene	0.60
MMP1	activates	gene	0.60
GPX4	activates	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SLC7A11	activates	gene	0.60
SOX9	activates	gene	0.60
ROS	activates	gene	0.60
MMP3	activates	gene	0.60
PIEZO1	regulates	gene	0.60
PIEZO	regulates	gene	0.60
P38	contributes_to	gene	0.60
DEMENTIA	causes	gene	0.60
TAU	causes	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
AMYLOID	causes	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
IL-1	causes	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
GLUT1	activates	gene	0.60
GBM	activates	gene	0.60
PERK	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
P2X7	activates	gene	0.60
NRF2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN in their description or question text

No additional research found