protein

Interleukin

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Interleukin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

678Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Interleukin
Associated Diseases	Aging, Als, Alzheimer, Anxiety, Atherosclerosis, Cancer
Interactions	IL-10, RIPK1, PPARG, WNT, TFEB, CFTR
KG Connections	674 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Interleukin["Interleukin"] -->|"regulates"| Fibrosis["Fibrosis"]
    style Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Interleukin["Interleukin"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Interleukin["Interleukin"] -->|"interacts"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Interleukin["Interleukin"] -->|"therapeutic target"| Multiple_Sclerosis["Multiple Sclerosis"]
    style Multiple_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Interleukin["Interleukin"] -->|"therapeutic target"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Interleukin["Interleukin"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Interleukin["Interleukin"] -->|"activates"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    REL["REL"] -->|"regulates"| Interleukin["Interleukin"]
    style REL fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_10["IL-10"] -->|"activates"| Interleukin["Interleukin"]
    style IL_10 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CERS2["CERS2"] -->|"regulates"| Interleukin["Interleukin"]
    style CERS2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IGF1R["IGF1R"] -->|"regulates"| Interleukin["Interleukin"]
    style IGF1R fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DAG1["DAG1"] -->|"regulates"| Interleukin["Interleukin"]
    style DAG1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Interleukin fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (197)

Target	Relation	Type	Str
Fibrosis	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Fibrosis	interacts_with	disease	0.60
Cancer	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Cancer	expressed_in	disease	0.60
Als	regulates	disease	0.60
Cancer	inhibits	disease	0.60
Neurodegeneration	activates	disease	0.60
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Stroke	activates	disease	0.60
Als	expressed_in	disease	0.60
Aging	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	regulates	disease	0.60
Als	inhibits	disease	0.60
Anxiety	activates	disease	0.60
Pyroptosis	activates	disease	0.60
Alzheimer	associated_with	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Anxiety	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Aging	associated_with	disease	0.60
Als	associated_with	disease	0.60
Parkinson	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Cancer	regulates	disease	0.60
Obesity	therapeutic_target	disease	0.60
Leukemia	inhibits	disease	0.60
Aging	therapeutic_target	disease	0.60
Neuropathy	expressed_in	disease	0.60
Als	contributes_to	disease	0.60
Ferroptosis	activates	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Senescence	biomarker_for	disease	0.60
Diabetes	inhibits	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Dementia	causes	disease	0.60
Alzheimer	contributes_to	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Cancer	activates	disease	0.60
Glioblastoma	activates	disease	0.60

Incoming (481)

Source	Relation	Type	Str
REL	regulates	gene	0.60
IL-10	activates	gene	0.60
CERS2	regulates	gene	0.60
IGF1R	regulates	gene	0.60
DAG1	regulates	gene	0.60
RNA	regulates	gene	0.60
ROS	regulates	gene	0.60
HSPG2	regulates	gene	0.60
RIPK1	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
AQP4	inhibits	gene	0.60
CD19	inhibits	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
COMPLEMENT	inhibits	gene	0.60
CRH	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
ESR1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
JUN	activates	gene	0.60
NR3C2	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
IL12	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
FOXP3	associated_with	gene	0.60
CYTOKINES	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
FOXP3	regulates	gene	0.60
IL-17	inhibits	gene	0.60
CD4	regulates	gene	0.60
TGFB1	regulates	gene	0.60
PARP1	inhibits	gene	0.60
EGR2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Interleukin

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Microglial Cells — Cell Type Hierarchy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Astrocyte Reactivity Mechanism

Oligodendrocytes

Blood-Brain Barrier Dysfunction in Neurodegeneration

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Vitamin D Signaling Pathway in Neurodegeneration

substantia-nigra

Histamine

Non-Homologous End Joining in Neurodegeneration

Calcium Signaling Dysregulation in Parkinson's Disease

Cellular Senescence in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

cynata-therapeutics