Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INFLAMMAGING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | INFLAMMAGING |
Knowledge base pages for this entity
graph TD
INFLAMMAGING["INFLAMMAGING"]
INFLAMMAGING -->|"mediates"| Chronic_Low_Grade_Systemic_Inf["Chronic Low-Grade Systemic Inflammation"]
INFLAMMAGING -->|"causes"| Age_Associated_Diseases["Age-Associated Diseases"]
INFLAMMAGING -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
INFLAMMAGING -->|"risk_factor_for"| Cardiovascular_Disease["Cardiovascular Disease"]
INFLAMMAGING -->|"risk_factor_for"| Metabolic_Disorders["Metabolic Disorders"]
INFLAMMAGING -->|"promotes"| neurodegeneration["neurodegeneration"]
INFLAMMAGING -->|"contributes to"| Neurodegenerative_Disorders["Neurodegenerative Disorders"]
Pro_Inflammatory_Cytokines["Pro-Inflammatory Cytokines"] -->|"involved_in"| INFLAMMAGING
Immunosenescence["Immunosenescence"] -->|"contributes to"| INFLAMMAGING
Cellular_Senescence["Cellular Senescence"] -->|"contributes to"| INFLAMMAGING
NF__B["NF-kappaB"] -->|"upstream_of"| INFLAMMAGING
Oxidative_Stress["Oxidative Stress"] -->|"contributes to"| INFLAMMAGING
Senescent_Microglia["Senescent Microglia"] -->|"contributes to"| INFLAMMAGING
Circadian_Clock_Dysfunction["Circadian Clock Dysfunction"] -->|"contributes to"| INFLAMMAGING
Immune_Homeostasis["Immune Homeostasis"] -->|"modulates"| INFLAMMAGING| Target | Relation | Type | Str |
|---|---|---|---|
| Chronic Low-Grade Systemic Inflammation | mediates | phenotype | 0.95 |
| Chronic Inflammation | associated_with | process | 0.95 |
| Chronic, Low-Grade, Systemic Inflammation | causes | phenotype | 0.95 |
| Age-Associated Diseases | causes | disease | 0.90 |
| Neurodegeneration | contributes_to | disease | 0.90 |
| senescence | associated_with | process | 0.90 |
| Osteoarthritis | contributes_to | disease | 0.90 |
| Cardiovascular Disease | risk_factor_for | disease | 0.85 |
| Metabolic Disorders | risk_factor_for | disease | 0.85 |
| neurodegeneration | promotes | disease | 0.85 |
| Neurodegeneration | risk_factor_for | disease | 0.85 |
| Neurodegenerative Disorders | contributes_to | disease | 0.80 |
| Infections | involved_in | disease | 0.80 |
| Neurodegenerative Disorders | involved_in | disease | 0.80 |
| Cancer | involved_in | disease | 0.80 |
| Dementia | involved_in | disease | 0.80 |
| Dopaminergic Neurons | associated_with | cell_type | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Pro-Inflammatory Cytokines | involved_in | protein | 0.90 |
| Immunosenescence | contributes_to | process | 0.90 |
| Cellular Senescence | contributes_to | process | 0.90 |
| NF-κB | upstream_of | pathway | 0.88 |
| Senescent Microglia | contributes_to | cell_type | 0.85 |
| Young plasma | treats | compound | 0.85 |
| IL-6 | associated_with | protein | 0.85 |
| Oxidative Stress | contributes_to | process | 0.85 |
| Cellular Senescence | associated_with | process | 0.85 |
| Circadian Clock Dysfunction | contributes_to | mechanism | 0.80 |
| Immune Homeostasis | modulates | process | 0.80 |
| dysbiosis | promotes | phenotype | 0.80 |
| Immune Homeostasis | interacts_with | process | 0.80 |
| cellular senescence | mediates | process | 0.80 |
| Lipid Accumulation | associated_with | process | 0.75 |
| CD300F | regulates | protein | 0.60 |
| CD300F | inhibits | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||