cell_type

Cellular Senescence

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cellular Senescence: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

306Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	Cellular Senescence
Related Genes	AMPK
Linked Hypotheses	8 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Cellular_Senescence["Cellular Senescence"] -->|"involved in"| Cardiac_Aging["Cardiac Aging"]
    style Cardiac_Aging fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Cellular_Senescence["Cellular Senescence"] -->|"causes"| Cell_Cycle_Arrest["Cell Cycle Arrest"]
    style Cell_Cycle_Arrest fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Cellular_Senescence["Cellular Senescence"] -->|"causes"| Apoptosis_Resistance["Apoptosis Resistance"]
    style Apoptosis_Resistance fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Cellular_Senescence["Cellular Senescence"] -->|"causes"| Senescence_Associated_Secretor["Senescence-Associated Secretory Phenotype"]
    style Senescence_Associated_Secretor fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Cellular_Senescence["Cellular Senescence"] -->|"expressed in"| Dopaminergic_Neurons["Dopaminergic Neurons"]
    style Dopaminergic_Neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Cellular_Senescence["Cellular Senescence"] -->|"mediates"| Senescence_Associated_Secretom["Senescence-Associated Secretome"]
    style Senescence_Associated_Secretom fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Cellular_Senescence["Cellular Senescence"] -->|"involved in"| Biological_Aging["Biological Aging"]
    style Biological_Aging fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Lipid_Accumulation["Lipid Accumulation"] -->|"causes"| Cellular_Senescence["Cellular Senescence"]
    style Lipid_Accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AMPK["AMPK"] -->|"regulates"| Cellular_Senescence["Cellular Senescence"]
    style AMPK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Telomere_Dysfunction["Telomere Dysfunction"] -->|"causes"| Cellular_Senescence["Cellular Senescence"]
    style Telomere_Dysfunction fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PGAM5["PGAM5"] -->|"modulates"| Cellular_Senescence["Cellular Senescence"]
    style PGAM5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"causes"| Cellular_Senescence["Cellular Senescence"]
    style Mitochondrial_Dysfunction fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style Cellular_Senescence fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (88)

Target	Relation	Type	Str
Cardiac Aging	involved_in	process	0.95
Cell Cycle Arrest	causes	phenotype	0.95
Apoptosis Resistance	causes	phenotype	0.95
Senescence-Associated Secretory Phenotype	causes	phenotype	0.95
ALZHEIMER'S DISEASE	causes	disease	0.95
PARKINSON'S DISEASE	causes	disease	0.95
Inflammation	promotes	process	0.95
Neurodegeneration	associated_with	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Alzheimer Disease	contributes_to	disease	0.95
Alzheimer'S Disease Pathology	mediates	mechanism	0.92
Dopaminergic Neurons	expressed_in	cell_type	0.90
Senescence-Associated Secretome	mediates	pathway	0.90
Biological Aging	involved_in	process	0.90
Aging	contributes_to	process	0.90
Chronic Aging-Related Diseases	contributes_to	disease	0.90
Senescence Biomarkers	biomarker_for	biomarker	0.90
Chronic Inflammation	contributes_to	process	0.90
Aging	involved_in	process	0.90
Biological Aging	mediates	process	0.90
Senescence-Associated Secretory Phenotype	mediates	phenotype	0.90
Senescence-Associated Secretory Phenotype	associated_with	phenotype	0.90
Inflammaging	contributes_to	process	0.90
Neuroinflammation	contributes_to	process	0.90
Embryonic Development	involved_in	process	0.90
Wound Healing	involved_in	process	0.90
Obesity	associated_with	disease	0.90
Inflammation	causes	process	0.90
NEURODEGENERATION	contributes_to	process	0.90
AGING	associated_with	process	0.90
Cellular Dysfunction	contributes_to	phenotype	0.90
Neuroinflammation	promotes	process	0.90
Neurodegenerative Diseases	contributes_to	disease	0.90
Osteoarthritis	contributes_to	disease	0.88
Cognitive Deficits	causes	phenotype	0.88
Myocardial Ischemia And Infarction	involved_in	disease	0.87
Heart Failure	involved_in	disease	0.85
Myocardial Ischemia	involved_in	disease	0.85
Myocardial Infarction	involved_in	disease	0.85
Myocardial Ischemia and Infarction	involved_in	disease	0.85
Aging	associated_with	process	0.85
Brain Aging	involved_in	process	0.85
Neurodegenerative Disease	associated_with	disease	0.85
Apoptosis	associated_with	process	0.85
Inflammaging	associated_with	process	0.85
TAU	contributes_to	protein	0.85
NEURON	expressed_in	cell_type	0.85
ASTROCYTES	expressed_in	cell_type	0.85
Immune System	involved_in	cell_type	0.85
Amyloid Plaque	promotes	biomarker	0.85

Incoming (218)

Source	Relation	Type	Str
Lipid Accumulation	causes	process	0.95
AMPK	regulates	protein	0.95
Telomere Dysfunction	causes	mechanism	0.95
PGAM5	modulates	protein	0.95
Mitochondrial Dysfunction	causes	process	0.95
Ginkgetin	associated_with	compound	0.95
MIR-302B	associated_with	gene	0.95
cGAS/STING	regulates	pathway	0.95
Ginkgetin	inhibits	compound	0.95
Mir-302B	associated_with	biomarker	0.95
Cgas/Sting Signaling	regulates	pathway	0.95
Lipid Accumulation	promotes	process	0.95
Dasatinib	inhibits	drug	0.95
Quercetin	inhibits	compound	0.95
Alzheimer'S Disease	associated_with	disease	0.95
SRT2104	suppresses	drug	0.93
Glucocerebrosides	causes	compound	0.90
Obesity	associated_with	phenotype	0.90
Metabolic Reprogramming	associated_with	process	0.90
Prediabetes	associated_with	disease	0.90
SIRT1	regulates	gene	0.90
IL23R	biomarker_for	protein	0.90
iPSC Reprogramming	associated_with	process	0.90
Partial Reprogramming	associated_with	process	0.90
Lysosomal Impairment	associated_with	process	0.90
MTOR	involved_in	gene	0.90
Microglia	involved_in	cell_type	0.90
Astrocytes	involved_in	cell_type	0.90
SDA-2026-04-01-gap-013	investigates	analysis	0.90
Intermittent Fasting	modulates	drug	0.90
CDKN1A	associated_with	protein	0.90
CDKN2A	associated_with	protein	0.90
BHB	suppresses	compound	0.90
Hayflick Limit	biomarker_for	biomarker	0.88
Aging	associated_with	phenotype	0.85
Caloric Restriction	inhibits	process	0.85
Aging	contributes_to	process	0.85
Glucocerebrosides	contributes_to	compound	0.85
Autophagy	regulates	process	0.85
OCT4	associated_with	gene	0.85
SOX2	associated_with	gene	0.85
KLF4	associated_with	gene	0.85
MYC	associated_with	gene	0.85
Cell Proliferation Arrest	associated_with	process	0.85
Epigenetic Clock Reset	modulates	mechanism	0.85
Autophagy	involved_in	process	0.85
Cgas-Sting Pathway	involved_in	pathway	0.85
Hayflick Limit	involved_in	mechanism	0.85
SASP	biomarker_for	phenotype	0.85
Aging	involved_in	process	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Cellular Senescence

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

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Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Device Therapies Comparison for CBS/PSP

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD) Mechanistic Pathway

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV

University of Heidelberg

rankings

VEGF/Angiogenesis Pathway in Neurodegeneration

Epigenetic Dysregulation in Neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Locus Coeruleus Alpha Neurons

Protein Aggregation Comparison in Neurodegeneration

NPAS3 Gene