disease

Osteoarthritis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Osteoarthritis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

372Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	OXIDATIVE STRESS, AMPK, INFLAMMATION, AUTOPHAGY, MITOCHONDRIAL DYSFUNCTION, CHONDROCYTE APOPTOSIS, APOPTOSIS, MAPK8
Therapeutic Agents	α-Ketoglutarate, Icariin, Perillaldehyde
KG Connections	357 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Safety and Clinical Outcomes Study: Amniotic and Umbilical Cord Tissue Admini... (NCT03899298)

clinical · 3028 words

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Pathway Diagram

graph TD
    Osteoarthritis["<b>Osteoarthritis</b>"]
    Inflammation{"Inflammation"}
    Osteoarthritis -->|"therapeutic_target"| Inflammation
    Als{"Als"}
    Osteoarthritis -->|"therapeutic_target"| Als
    Apoptosis["Apoptosis"]
    Osteoarthritis -->|"therapeutic_target"| Apoptosis
    Aging{"Aging"}
    Osteoarthritis -->|"therapeutic_target"| Aging
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"therapeutic_target"| Osteoarthritis
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"therapeutic_target"| Osteoarthritis
    AMPK(["AMPK"])
    AMPK -->|"activates"| Osteoarthritis
    style Osteoarthritis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (116)

Target	Relation	Type	Str
Inflammation	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Aging	therapeutic_target	disease	1.00
Aging	associated_with	disease	0.95
Inflammation	associated_with	disease	0.95
Mtor	activates	pathway	0.90
Chondrocytes	associated_with	cell_type	0.85
Als	activates	disease	0.85
Als	associated_with	disease	0.85
Chondrocyte Senescence	associated_with	biological_process	0.80
Mtor	therapeutic_target	pathway	0.80
Autophagy	associated_with	pathway	0.80
Senescence	associated_with	pathway	0.80
Cancer	associated_with	disease	0.75
Ferroptosis	activates	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Autophagy	implicated_in	pathway	0.70
Mitophagy	implicated_in	pathway	0.70
Apoptosis	associated_with	pathway	0.70
Ampk Signaling	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Autophagy	treats	pathway	0.70
Mitophagy	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
Mitophagy	regulates	pathway	0.70
Cancer	therapeutic_target	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Aging	contributes_to	disease	0.65
Osteoporosis	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Wnt	therapeutic_target	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Microrna	therapeutic_target	pathway	0.60
Apoptosis	causes	pathway	0.60
Ampk Signaling	causes	pathway	0.60
Differentiation	implicated_in	pathway	0.60
Mtor	implicated_in	pathway	0.60
Mapk	implicated_in	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
Mtor	treats	pathway	0.60
Oxidative Stress	treats	pathway	0.60
Mitochondrial Function	treats	pathway	0.60

Incoming (256)

Source	Relation	Type	Str
INFLAMMATION	therapeutic_target	gene	1.00
INFLAMMATION	associated_with	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
AMPK	activates	gene	1.00
Mitophagy	involved_in	process	0.95
AGING	associated_with	gene	0.95
Ageing	risk_factor_for	process	0.95
Iron Overload	risk_factor_for	process	0.90
Inflammaging	contributes_to	mechanism	0.90
ALOX5	associated_with	gene	0.88
Perillaldehyde	treats	compound	0.88
Cellular Senescence	contributes_to	process	0.88
Oxidative Stress	causes	process	0.85
Extracellular Matrix Degradation	causes	process	0.85
Rapamycin	protects_against	drug	0.85
PI3K	activates	gene	0.85
PI3K	therapeutic_target	gene	0.85
AKT	therapeutic_target	gene	0.85
MTOR	therapeutic_target	gene	0.85
ROS	activates	gene	0.85
AUTOPHAGY	associated_with	gene	0.85
Icariin	treats	compound	0.85
Cell Apoptosis	contributes_to	process	0.85
Mitochondrial Quality Control	protects_against	process	0.80
α-Ketoglutarate	treats	compound	0.80
Mitophagy Regulation	treats	mechanism	0.80
Sensory Nerve Regulation	associated_with	mechanism	0.80
Intercellular Mitochondrial Transfer	therapeutic_target	process	0.80
Reduced AMPK Activity	contributes_to	mechanism	0.80
Mesenchymal Stromal Cells	treats	cell_type	0.75
FERROPTOSIS	activates	gene	0.75
AKT	activates	gene	0.75
MTOR	activates	gene	0.75
CYTOKINES	therapeutic_target	gene	0.75
NF-ΚB	therapeutic_target	gene	0.75
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
CHONDROCYTE APOPTOSIS	therapeutic_target	gene	0.75
CANCER	therapeutic_target	gene	0.75
Tumor	therapeutic_target	disease	0.75
Diabetes	associated_with	disease	0.75
AUTOPHAGY	implicated_in	gene	0.75
MITOPHAGY	implicated_in	gene	0.75
APOPTOSIS	associated_with	gene	0.75
CHONDROCYTE AUTOPHAGY	activates	gene	0.75
MTORC1	activates	gene	0.75
CYTOKINES	activates	gene	0.75
AUTOPHAGY	activates	gene	0.75
AUTOPHAGY	treats	gene	0.75
PINK1	activates	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Osteoarthritis

Understanding Entity Pages

Wiki Pages (20)

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Safety and Clinical Outcomes Study: Amniotic and Umbilical Cord Tissue Admini... (NCT03899298)

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