CELLULAR SENESCENCE

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELLULAR SENESCENCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    CELLULAR_SENESCENCE["CELLULAR SENESCENCE"]
    style CELLULAR_SENESCENCE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CELLULAR_SENESCENCE -->|"involved_in"| Cardiac_Aging["Cardiac Aging"]
    CELLULAR_SENESCENCE -->|"causes"| Cell_Cycle_Arrest(Cell Cycle Arrest)
    CELLULAR_SENESCENCE -->|"causes"| Apoptosis_Resistance(Apoptosis Resistance)
    CELLULAR_SENESCENCE -->|"causes"| Senescence_Associated_Secretor(Senescence-Associated Secretory Phenotype)
    CELLULAR_SENESCENCE -->|"causes"| cell_cycle_arrest(cell cycle arrest)
    CELLULAR_SENESCENCE -->|"promotes"| pro_inflammatory_molecules["pro-inflammatory molecules"]
    CELLULAR_SENESCENCE -->|"expressed in"| Dopaminergic_Neurons["/Dopaminergic Neurons/"]
    CELLULAR_SENESCENCE -->|"mediates"| Senescence_Associated_Secretom["Senescence-Associated Secretome"]
    CELLULAR_SENESCENCE -->|"involved_in"| Biological_Aging["Biological Aging"]
    CELLULAR_SENESCENCE -->|"contributes to"| Aging["Aging"]
    Lipid_Accumulation["Lipid Accumulation"] -->|"causes"| CELLULAR_SENESCENCE
    AMPK([AMPK]) -->|"regulates"| CELLULAR_SENESCENCE
    LIPID_ACCUMULATION["LIPID ACCUMULATION"] -->|"causes"| CELLULAR_SENESCENCE
    Telomere_Dysfunction["Telomere Dysfunction"] -->|"causes"| CELLULAR_SENESCENCE
    PGAM5([PGAM5]) -->|"modulates"| CELLULAR_SENESCENCE
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"causes"| CELLULAR_SENESCENCE
    P53([P53]) -->|"promotes"| CELLULAR_SENESCENCE
    cGAS_STING["cGAS/STING"] -->|"regulates"| CELLULAR_SENESCENCE
    cGAS_STING_signaling_pathway["cGAS/STING signaling pathway"] -->|"regulates"| CELLULAR_SENESCENCE
    Ginkgetin{"Ginkgetin"} -.->|"prevents"| CELLULAR_SENESCENCE