gene

KCNK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections
0Hypotheses
0Analyses
16Outgoing
7Incoming

Summary

KCNK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Als, Fibrosis. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolKCNK1
Full NamePotassium Two Pore Domain Channel Subfamily K Member 1
AliasesTWIK-1, K2P1.1, TASK-1 (related family)
Chromosome1q42.12
Functionencodes the TWIK-1 potassium channel, a member of the two-pore domain (K2P) potassium channel family
Exons4
PathwaysInteraction
UniProt IDO00180
NCBI Gene ID3775
Ensembl IDENSG00000135750
OMIM603457
GeneCardsKCNK1
Human Protein AtlasKCNK1
Gene Length7.8 kb
Resting membrane potentialBackground K+ leak conductance
Associated Diseasesneurodegeneration
InteractionsKCNK2, AND
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KCNK1 — AlphaFold O00180 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

KCNK1 Gene - Two-Pore Domain Potassium Channel

gene · 984 words

KCNK15 Protein — TASK-5 Potassium Channel

protein · 1954 words

kcnk6-protein

protein · 1574 words

KCNK3 Gene

gene · 964 words

KCNK6 Gene

gene · 814 words

KCNK3 Protein (TASK-1 Potassium Channel)

protein · 669 words

Pathway Diagram

graph TD
    KCNK1["<b>KCNK1</b>"]
    TWIK1["TWIK1"]
    KCNK1 -->|"encodes"| TWIK1
    Hypertension{"Hypertension"}
    KCNK1 -->|"activates"| Hypertension
    Heart_Failure{"Heart Failure"}
    KCNK1 -->|"activates"| Heart_Failure
    Als{"Als"}
    KCNK1 -->|"activates"| Als
    Fibrosis{"Fibrosis"}
    KCNK1 -->|"inhibits"| Fibrosis
    KCNK1 -->|"inhibits"| Als
    ALS{"ALS"}
    KCNK1 -->|"activates"| ALS
    CELL_PROLIFERATION["CELL_PROLIFERATION"]
    KCNK1 -->|"activates"| CELL_PROLIFERATION
    KCNK3["KCNK3"]
    KCNK1 -->|"regulates"| KCNK3
    KCNK6["KCNK6"]
    KCNK1 -->|"regulates"| KCNK6
    PAH["PAH"]
    KCNK1 -->|"regulates"| PAH
    KCNK2["KCNK2"]
    KCNK1 -->|"activates"| KCNK2
    KCNK2 -->|"activates"| KCNK1
    PAH -->|"regulates"| KCNK1
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| KCNK1
    KCNK6 -->|"associated with"| KCNK1
    KCNK6 -->|"regulates"| KCNK1
    AND["AND"]
    AND -->|"activates"| KCNK1
    KCNK3 -->|"regulates"| KCNK1
    style KCNK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

TargetRelationTypeStr
TWIK1encodesprotein0.72
Hypertensionactivatesdisease0.65
Heart Failureactivatesdisease0.65
Alsactivatesdisease0.65
Fibrosisinhibitsdisease0.65

Incoming (7)

SourceRelationTypeStr
KCNK2activatesgene0.60
PAHregulatesgene0.60
KCNK5associated_withgene0.60
KCNK6associated_withgene0.60
KCNK6regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found