gene

KIF2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KIF2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

16Outgoing

0Incoming

Summary

KIF2A is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, associated with. Associated with Cancer, DLBCL, Epilepsy. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KIF2A
Full Name	Kinesin Family Member 2A
Chromosome	5q12.1
Protein Type	Kinesin-13 family (microtubule depolymerase)
Function	KIF2A is a unique motor protein that does not transport cargo in the traditional sense but instead regulates microtubule dynamics through its depolymerizing activity.
UniProt ID	O00139
NCBI Gene ID	9583
Ensembl ID	ENSG00000145833
OMIM	607349
GeneCards	KIF2A
Human Protein Atlas	KIF2A
Protein Class	Kinesin-13 family (microtubule depolymerase)
Motor domain (N-terminal)	aa 1-350
Neck	aa 351-400
Stalk	aa 401-650
Associated Diseases	DLBCL, glioma
Interactions	Notch1
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KIF2A — AlphaFold O00139 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    KIF2A["<b>KIF2A</b>"]
    Notch1["Notch1"]
    KIF2A -->|"interacts with"| Notch1
    glioma{"glioma"}
    KIF2A -->|"associated with"| glioma
    apoptosis["apoptosis"]
    KIF2A -->|"inhibits"| apoptosis
    DLBCL{"DLBCL"}
    KIF2A -->|"associated with"| DLBCL
    AGAP1["AGAP1"]
    KIF2A -->|"binds"| AGAP1
    cell_spreading["cell_spreading"]
    KIF2A -->|"inhibits"| cell_spreading
    Epilepsy{"Epilepsy"}
    KIF2A -->|"regulates"| Epilepsy
    Cancer{"Cancer"}
    KIF2A -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    KIF2A -->|"therapeutic target"| Tumor
    Ms{"Ms"}
    KIF2A -->|"therapeutic target"| Ms
    GENES["GENES"]
    KIF2A -->|"therapeutic target"| GENES
    DNA["DNA"]
    KIF2A -->|"therapeutic target"| DNA
    style KIF2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Notch1	interacts_with	gene	0.80
glioma	associated_with	disease	0.80
DLBCL	associated_with	disease	0.80
AGAP1	binds	gene	0.80
cell_spreading	inhibits	biological_process	0.70
Epilepsy	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
RPL27A	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KIF2A

Understanding Entity Pages

Summary

Wiki Pages (7)

KIF2A — Kinesin Family Member 2A

RPL27A — Ribosomal Protein L27A

Syntaxin-1B (STX1B)

DYNC1H1 — Dynein Cytoplasmic 1 Heavy Chain 1

Kinesin Family Member 2A (KIF2A)