pathway

WNT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3033Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	WNT
Key Genes/Proteins	AB, ACHE, ACSL5, Actin, ACVR2A, AD
Related Diseases	aging, Aging
Related Pathways	Akt
Linked Hypotheses	1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WNT["WNT"] -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    WNT["WNT"] -->|"activates"| Carcinoma["Carcinoma"]
    WNT["WNT"] -->|"expressed in"| Cancer["Cancer"]
    WNT["WNT"] -->|"expressed in"| Tumor["Tumor"]
    WNT["WNT"] -->|"contributes to"| Tumor_1["Tumor"]
    WNT["WNT"] -->|"contributes to"| Cancer_2["Cancer"]
    FZD3["FZD3"] -->|"participates in"| WNT["WNT"]
    FZD3_3["FZD3"] -->|"binds"| WNT["WNT"]
    PSMB1["PSMB1"] -->|"activates"| WNT["WNT"]
    BECN1["BECN1"] -->|"activates"| WNT["WNT"]
    style WNT fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1046)

Target	Relation	Type	Str
WNT	encodes	protein	0.00
synaptic plasticity	regulates	process	0.95
neurogenesis	regulates	process	0.95
neuroinflammation	regulates	process	0.90
Wnt/β-catenin signaling	part_of	pathway	0.90
Synapse Remodeling	regulates	process	0.90
Neurodevelopment	involved_in	process	0.90
beta-catenin	regulates	protein	0.90
PFKM	downregulates	protein	0.90
Autophagy	interacts_with	process	0.90
vascular remodeling	modulates	process	0.85
Parkinson's Disease	protects_against	disease	0.85
Alzheimer's Disease	protects_against	disease	0.85
autophagy	suppresses	process	0.85
stroke	protects_against	disease	0.85
Autophagy	interacts_with	process	0.85
Amyotrophic Lateral Sclerosis	protects_against	disease	0.85
autophagy	mediates	process	0.80
Wnt signaling	participates_in	pathway	0.80
Autism-Like Behaviors	mediates	phenotype	0.80
Pulmonary Arterial Hypertension	associated_with	disease	0.80
endothelial cells	expressed_in	cell_type	0.80
β-catenin	interacts_with	protein	0.80
NF-κB	interacts_with	pathway	0.80
PI3K/AKT	interacts_with	pathway	0.80
Wnt3	part_of	protein	0.80
BMP	interacts_with	pathway	0.80
Alzheimer's disease	associated_with	disease	0.80
TGF-β	interacts_with	pathway	0.80
Hepatocellular Carcinoma	causes	disease	0.80
PULMONARY HYPERTENSION	involved_in	entity	0.75
embryo development	modulates	process	0.75
Pulmonary Arterial Hypertension	involved_in	disease	0.75
oxidative stress response	participates_in	pathway	0.70
glioblastoma	activates	disease	0.70
autophagy pathway	participates_in	pathway	0.70
neural stem cells	activates	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
GBM	associated_with	disease	0.70
glioblastoma multiforme	regulates	disease	0.70
GSK-3β	regulates	protein	0.70
DKK1	inhibits	protein	0.70
β-catenin	inhibits	protein	0.70
CI-994	modulates	drug	0.70
TMJOA	associated_with	disease	0.70
Anxiety	activates	disease	0.65
Als	encodes	disease	0.65
Cardiovascular	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Fibrosis	activates	disease	0.65

Incoming (1987)

Source	Relation	Type	Str
WNT	encodes	gene	0.00
GENES	activates	gene	1.00
AKT	associated_with	gene	1.00
Cancer	activates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
AKT	therapeutic_target	gene	1.00
MTOR	therapeutic_target	gene	1.00
Als	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
CANCER	activates	gene	1.00
AKT	activates	gene	1.00
Inflammation	activates	disease	1.00
PI3K	activates	gene	1.00
Als	regulates	disease	1.00
Tumor	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
PI3K	associated_with	gene	1.00
EGFR	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
P53	activates	gene	1.00
CANCER	regulates	gene	1.00
MTOR	associated_with	gene	1.00
P53	associated_with	gene	1.00
Carcinoma	activates	disease	1.00
PI3K	therapeutic_target	gene	1.00
AKT	regulates	gene	1.00
AMYLOID	associated_with	protein	0.98
Bnt162B2	associated_with	drug	0.95
Cancer	regulates	disease	0.95
CTNNB1	involved_in	gene	0.95
DKK1	inhibits	gene	0.90
Thermal adaptation	inhibits	process	0.90
APOPTOSIS	regulates	gene	0.90
PI3K	regulates	gene	0.90
NF-ΚB	activates	gene	0.90
Colorectal Cancer	activates	disease	0.90
ROS	activates	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
GENES	therapeutic_target	gene	0.90
INFLAMMATION	therapeutic_target	gene	0.90
Microglia	activates	cell_type	0.85
BNT162b2	modulates	drug	0.85
NOTUM	inhibits	gene	0.85
DVL3	regulates	gene	0.85

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Wnt/β-catenin Pathway Restoration	0.686	-	Blood-brain barrier tight junction disru
Inhibitory Neuron-Selective WNT Signaling Restoration	0.554	neurodegeneration	Which cell types show the most significa
NETs-MMP-Wnt Axis Therapeutic Cascade	0.000	-	Blood-brain barrier tight junction disru

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT in their description or question text

No additional research found

WNT

Understanding Entity Pages

Wiki Pages (21)

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

WNT4 Gene

WNT7A Gene

WNT2B Gene - Wnt Family Member 2B

WNT3 Gene

WNT10A Gene

WNT5B Gene

WNT7B Gene - Wnt Family Member 7B

DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1

WNT11 Gene

WNT8A Gene

WNT9B Gene

WNT1 Gene

WNT1 Protein

WNT9A — Wnt Family Member 9A

WNT6 — Wnt Family Member 6

WNT2 Gene

WNT2 Protein

AD WNT Signaling and Developmental Pathway Companies

WNT3A Gene

WNT8B Gene