gene

Wnt

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Wnt: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2940Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Wnt is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 988 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WNT
Primary Expression	Cortex, Brainstem, Thalamus, Hippocampus, Entorhinal Cortex
Pathways	Wnt signaling, PI3K/AKT, TGF-β, NF-κB, BMP
GeneCards	WNT
Human Protein Atlas	WNT
Strong Genetic Evidence	Multiple Wnt pathway genes (LRP5, FZD3, GSK3B, AXIN1) show reproducible associations with PD risk in GWAS and exome sequencing studies
Strong Preclinical Evidence	Consistent neuroprotection in toxin models (MPTP, 6-OHDA) across multiple species with Wnt pathway activation
Moderate Human Evidence	Post-mortem studies show consistent Wnt pathway alterations in PD brains, though causal direction remains uncertain
Mechanistic Plausibility	Well-established pathway biology connecting Wnt signaling to mitochondrial function, neuroinflammation, and protein clearance
Associated Diseases	GBM, Pulmonary Arterial Hypertension
KG Connections	1482 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Wnt["Wnt"] -->|"regulates"| beta_catenin["beta-catenin"]
    Wnt["Wnt"] -->|"associated with"| GBM["GBM"]
    Wnt["Wnt"] -->|"regulates"| glioblastoma_multiforme["glioblastoma multiforme"]
    IDH1["IDH1"] -->|"therapeutic target"| Wnt["Wnt"]
    VEGFA["VEGFA"] -->|"therapeutic target"| Wnt["Wnt"]
    MDM4["MDM4"] -->|"therapeutic target"| Wnt["Wnt"]
    APOB["APOB"] -->|"therapeutic target"| Wnt["Wnt"]
    style Wnt fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1045)

Target	Relation	Type	Str
beta-catenin	regulates	protein	0.90
Autophagy	interacts_with	process	0.90
PI3K/AKT	interacts_with	pathway	0.80
TGF-β	interacts_with	pathway	0.80
NF-κB	interacts_with	pathway	0.80
BMP	interacts_with	pathway	0.80
Pulmonary Arterial Hypertension	associated_with	disease	0.80
GBM	associated_with	disease	0.70
glioblastoma multiforme	regulates	disease	0.70
Mapk	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Oxidative Phosphorylation	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Hedgehog	interacts_with	pathway	0.55
Ubiquitin-Proteasome	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Notch	interacts_with	pathway	0.55
Stem Cell	interacts_with	cell_type	0.50
Dendritic Cell	interacts_with	cell_type	0.50
Epithelial	regulates	cell_type	0.50
Monocyte	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Fibroblast	associated_with	cell_type	0.50
Endothelial	associated_with	cell_type	0.50
Neuron	encodes	cell_type	0.50
Interneuron	encodes	cell_type	0.50
Fibroblast	activates	cell_type	0.50
Stem Cell	regulates	cell_type	0.50
Osteoblast	regulates	cell_type	0.50
Osteoclast	regulates	cell_type	0.50
Neuron	expressed_in	cell_type	0.50
Microglia	inhibits	cell_type	0.50
Astrocyte	inhibits	cell_type	0.50
Neuron	inhibits	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Neuron	activates	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Neural Progenitor	regulates	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
Neuron	therapeutic_target	cell_type	0.50
Fibroblast	regulates	cell_type	0.50
Endothelial	transports	cell_type	0.50
Microglia	activates	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Epithelial	inhibits	cell_type	0.50

Incoming (1895)

Source	Relation	Type	Str
EGFR	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
GENES	activates	gene	1.00
Cancer	activates	disease	1.00
Cancer	associated_with	disease	1.00
Als	activates	disease	1.00
PI3K	associated_with	gene	1.00
AKT	associated_with	gene	1.00
Tumor	activates	disease	1.00
Als	regulates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
MTOR	therapeutic_target	gene	1.00
AKT	therapeutic_target	gene	1.00
PI3K	activates	gene	1.00
CANCER	activates	gene	1.00
AKT	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
INFLAMMATION	activates	gene	1.00
CANCER	associated_with	gene	1.00
MTOR	associated_with	gene	1.00
Carcinoma	therapeutic_target	disease	1.00
Carcinoma	activates	disease	1.00
AKT	regulates	gene	1.00
P53	associated_with	gene	1.00
PI3K	therapeutic_target	gene	1.00
CANCER	regulates	gene	1.00
P53	activates	gene	1.00
Cancer	regulates	disease	0.95
GENES	therapeutic_target	gene	0.90
PI3K	regulates	gene	0.90
INFLAMMATION	therapeutic_target	gene	0.90
NF-ΚB	activates	gene	0.90
APOPTOSIS	regulates	gene	0.90
AUTOPHAGY	regulates	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
AKT	contributes_to	gene	0.90
ROS	activates	gene	0.90
Colorectal Cancer	activates	disease	0.90
TENASCINC	associated_with	protein	0.80
Inflammation	regulates	disease	0.80
Inflammation	therapeutic_target	disease	0.80
MYC	therapeutic_target	gene	0.80
STAT3	regulates	gene	0.80
MTOR	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
P53	inhibits	gene	0.80
INFLAMMATION	regulates	gene	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibitory Neuron-Selective WNT Signaling Restoration	0.390	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positi [PMID:32248976]	Shen G, Gao Q, Liu F, Zhang Y, Dai M et	Biochem Biophys Res Commun	2020
WNT signalling in the normal human adult testis and in male germ cell neoplasms. [PMID:32667987]	Young JC, Kerr G, Micati D, Nielsen JE,	Hum Reprod	2020
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-cat [PMID:28811361]	Emons G, Spitzner M, Reineke S, Möller J	Mol Cancer Res	2017
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. [PMID:24605829]	Meinhardt G, Haider S, Haslinger P, Proe	Endocrinology	2014
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signa [PMID:15650056]	Tickenbrock L, Schwäble J, Wiedehage M,	Blood	2005

Wnt

Understanding Entity Pages

Summary

Wiki Pages (21)

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

Novel Therapy Index

Parkinson's Disease

Parthanatos in Neurodegeneration

Therapeutics

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

NTF4 Protein

GSK-3β in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Lithium for PSP/CBS — Phase 2 Trial

blood-brain-barrier

Spinal Cord Dorsal Horn Neurons

Niemann-Pick Disease Type C (NPC)

MACF1 — Microtubule-actin crosslinking factor 1

IGF-1 Signaling Pathway in Neurodegeneration

Cellular Reprogramming Therapies for Neurodegeneration

Notch Signaling Pathway in Neurodegeneration