entity

LAM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

25Hypotheses

30Analyses

2Outgoing

1Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (2)

Target	Relation	Type	Str
METABOLIC_HOMEOSTASIS	regulates	phenotype	0.68
WAT	expressed_in	cell_type	0.64

Incoming (1)

Source	Relation	Type	Str
TREM2	expressed_in	protein	0.72

Targeting Hypotheses (25)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Palmitoylethanolamide-Based Endocannabinoid Therapy	0.780	-	Blood-brain barrier tight junction disru
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.645	neurodegeneration	What are the precise temporal dynamics o
Alpha-gamma cross-frequency coupling enhancement to restore	0.621	Alzheimer's disease	Circuit-level neural dynamics in neurode
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam	0.617	neurodegeneration	What are the mechanisms by which gut mic
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.605	neuroinflammation	What molecular mechanisms drive the tran

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic
Microbial Inflammasome Priming Prevention	0.584	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.582	neurodegeneration	What are the mechanisms by which gut mic
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neu	0.580	neurodegeneration	What are the mechanisms by which gut mic
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.576	neuroinflammation	How do oligodendrocytes initiate neuroin
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl	0.575	neuroscience	Circuit-level neural dynamics in neurode
Thalamocortical Synchrony Restoration via NMDA Modulation	0.542	neuroscience	Circuit-level neural dynamics in neurode
HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting	0.526	synaptic biology	How do P/Q channel deficits paradoxicall
Peripheral-to-Central Inflammation Circuit Breaker	0.520	-	Blood-brain barrier tight junction disru
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.512	neurodegeneration	What are the mechanisms by which gut mic
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui
Cardiovascular-Neuroinflammatory Dual Targeting	0.462	neurodegeneration	Neuroinflammation and microglial priming
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.452	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.444	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Cardiovascular-Neuroinflammation Crosstalk Interruption	0.437	Alzheimer's disease	Neuroinflammation and microglial priming
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.424	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (30)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.780

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Systemic inflammation as a central player in the initiation and development of A [PMID:40841660]	Bayraktaroglu I, Ortí-Casañ N, Van Dam D	Immunity & ageing : I & A	2025	1
USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990]	["Di Q", "Zhao X", "Tang H", "Li X", "Xi	Autophagy	2023	1
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradatio [PMID:34486483]	["Cai B", "Zhao J", "Zhang Y", "Liu Y",	Autophagy	2022	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Interweaving microglial senescence and gut microbiome dynamics in Alzheimer's di [PMID:41747877]	Waghmare A, Rahangdale S, Khare K, Taksa	Molecular and cellular neurosc	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter [PMID:41687275]	Otálora-Alcaraz A, Sun MC, Hofman N, Cos	Multiple sclerosis and related	2026	0
NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adip [PMID:41596350]	Alenezi SA, Alshammari K, Khan R, Amer S	International journal of molec	2026	0
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086]	Li Z, Tan D, Lin J, Zhang T, Liu B et al	J Adv Res	2026	0
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111]	Cao F, Zhang P, Zheng Z, Wang P, Wang Y	Neurol Res	2026	0
CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399]	Zhang Y, Wang J, Song Y, Chai J, Li L et	Biochem Pharmacol	2026	0
Panax ginseng-derived Exosome-like Nanoparticles Prevent LPS-induced Septic Shoc [PMID:41530048]	Kim Y, Kim YK, Lee S, Kim M, Lee SW et a	Mol Pharm	2026	0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026	0
2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238]	Chen J, Liang S, Liu D, Yang S, Yan Q et	J Agric Food Chem	2026	0
Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324]	Yan H, Chia D, Ernst S, Demuytere J, Cos	Expert Opin Drug Deliv	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627]	Nakabo S, Hanata N, Patino-Martinez E, H	Arthritis Rheumatol	2026	0
In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545]	Zheng N, Xu Y	PLoS Negl Trop Dis	2026	0
Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597]	Ma B, Lyu W, Rizk J, Han X, Kjær M et al	Sci Immunol	2026	0

LAM

Understanding Entity Pages

Wiki Pages (20)

Mediterranean and MIND Diets for Neurodegeneration

rapamycin-tauopathy

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Complement-Mediated Synapse Loss

Tau Immunotherapy Mechanisms

Nav1.1 Sodium Channel

oga-inhibition-tau

EPHA1 Gene

fip200

sk4-protein

SLC9A1 — Sodium/Hydrogen Exchanger 1

HAR1 — Human Accelerated Region 1

GBA Glucocerebrosidase Dysfunction and Parkinson's Disease

HTR3C Gene

TRPM3 Gene - Transient Receptor Potential Channel

OPRM1 — Mu-Opioid Receptor

Type I Interferon Modulation Therapy for Neurodegeneration

Precision Medicine in Neurodegeneration

ADCY1 Gene

EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal Chain

Outgoing (2)

Incoming (1)

Targeting Hypotheses (25)

Mentioning Analyses (30)

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

How do P/Q channel deficits paradoxically increase thalamic excitability despite

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

What molecular mechanisms underlie the dose-dependent protective effects of the

What are the specific molecular mechanisms by which peripheral monocytes cross t

Extracellular vesicle biomarkers for early AD detection

Can TREM2 receptor switching from agonism to antagonism be achieved safely witho

Does tau aggregation specifically cause PS externalization in living cells versu

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Why do clinical manifestations overlap despite distinct underlying etiologies in

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

Can circadian interventions reverse microglial priming independent of sleep disr

What determines organelle-specific autophagy selectivity in neurodegenerative di

What are the specific pathophysiological mechanisms underlying uncommon immune-m

What specific astrocyte-derived factors can 'erase' pathological microglial memo

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

How do different organelle-specific autophagy pathways coordinate during neurode

What determines the selectivity of complement-mediated synaptic elimination in p

What causes IBA1 low/negative microglia in liver disease and how does this affec

Do microglia actually switch between glycolytic and oxidative phosphorylation as

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Neuroinflammation and microglial priming in early AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Papers (20)