| Gene Symbol | LAMP1 |
| Full Name | Lysosomal Associated Membrane Protein 1 |
| Aliases | LAMP1PROTEIN |
| Chromosome | 13q34 |
| Protein Family | LAMP family |
| Protein Type | Structural Protein |
| Target Class | Structural Protein |
| Function | Protects lysosomal membrane proteins from proteolytic degradation |
| Mechanism of Action | Direct LAMP1 modulators enhance lysosomal membrane trafficking and autophagy flux, while indirect pathway drugs alter lysosomal pH and autophagosome-lysosome fusion dynamics to modulate LAMP1-mediated cellular clearance mechanisms. |
| Primary Expression | Ubiquitous, highest in brain |
| Subcellular Localization | Lysosomes, Late Endosomes |
| Druggability | Low (0.43) |
| Clinical Stage | Phase I |
| Molecular Weight | ~120 kDa (glycosylated) |
| Amino Acids | 417 aa |
| Pathways | mTOR |
| UniProt ID | P11279 |
| GeneCards | LAMP1 |
| Human Protein Atlas | LAMP1 |
| Associated Diseases | AD, ADH, ALS, AMI, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, COENZYME Q10, rapamycin |
| Interactions | ATG7, JUN, CALCINEURIN, ATG12, ATG10, ACTB |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Lysosomal Positioning Dynamics Modulation |
| KG Connections | 1477 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |