gene 723 words KG: LAMP3 2026-03-24
kind:genesection:genesstate:published
Contents

Lysosomal Associated Membrane Protein 3 (LAMP3)

🧬 Gene Info
Gene SymbolLAMP3
Full NameLysosomal Associated Membrane Protein 3
Chromosome3q27.2.
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmature dendritic cells and plays critical roles in: - MHC class II antigen presentation: Colocalizes with MHC class II compartments - Immune syn
Molecular Weight61.7 kDa
UniProt ID[Q9UQ15](https://www.uniprot.org/uniprot/Q9UQ15)
Ensembl IDENSG00000046651
GeneCardsLAMP3
Human Protein AtlasLAMP3
Associated Diseasesneurodegeneration
KG Connections9 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Membrane Cholesterol Gradient Modulators
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Lysosomal Enzyme Trafficking Correction
Score: 0.49

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: expressed_in
TGM2 — Transglutaminase 2
gene · KG edge: expressed_in
RORA — RAR Related Orphan Receptor A
gene · KG edge: expressed_in
PIK3R1 Gene
gene · KG edge: expressed_in
NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2)
gene · KG edge: expressed_in

Knowledge Graph (9 edges)

LAMP3 expressed_in ABCG1
LAMP3 expressed_in RORA
LAMP3 expressed_in TGM2
LAMP3 expressed_in PIK3R1
LAMP3 expressed_in WTAP
LAMP3 expressed_in Als
NR1D2 expressed_in LAMP3
CKAP4 expressed_in LAMP3
GAIN expressed_in LAMP3