protein 833 words KG: LAMP2 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

LAMP2 Protein

🔬 Protein Info
Gene SymbolLAMP2
AliasesLysosomal-Associated Membrane Protein 2
ChromosomeXq24
Protein FamilyLAMP family
FunctionLAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight~110 kDa (heavily glycosylated)
Amino Acids410 aa
PathwaysApoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt IDP13473
Ensembl IDENSG00000143106
GeneCardsLAMP2
Human Protein AtlasLAMP2
Protein NameLAMP2
LocationLysosomal/endosomal membrane
ProteinDisease
Associated DiseasesALS, APOPTOSIS, AUTOPHAGY, Alzheimer, Cancer
Known Drugs/CompoundsRAPAMYCIN, statins, quercetin, rapamycin
InteractionsPLIN3, BECN1, GRK2, FOXO1, NR1H3, MAP3K5
KG Connections1117 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Lysosomal Membrane Repair Enhancement
Score: 0.45
Lysosomal Positioning Dynamics Modulation
Score: 0.43
VCP-Mediated Autophagy Enhancement
Score: 0.41
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67

Related Analyses (18)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

Related Experiments (1)

Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
ACLY Inhibition Rescues Alpha-Synuclein Autophagy
mechanism · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: activates
ACTB Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

LAMP2 associated_with GBM
LAMP2 associated_with LC3
LAMP2 associated_with EPG5
LAMP2 associated_with STX17
LAMP2 associated_with SQSTM1
LAMP2 associated_with SNAP29
LAMP2 associated_with SDC1
LAMP2 associated_with TGM2
LAMP2 associated_with DNM1L
LAMP2 associated_with ULK1